Differentiating clinical characteristics between two subtypes of antiphosphatidylethanolamine

摘要 抗磷脂酰乙醇胺(APE)自身抗体与抗磷脂临床症状相关 综合征(APS)。然而，APE的临床意义仍有待充分确立。在努力定义 猿类，我们发现猿类实际上由两个不同的亚型组成。这一概念是基于我们的发现 有两种类型的类人猿抗体-辅因子非依赖性(APEI)和辅因子依赖性(APED)，它们 有不同的抗原和致病机制。在目前的努力中，我们将调查临床上 APEI和APED抗体假设在一项回顾研究中的特征 与APS的临床和实验室标准有不同的联系。新的知识将有助于定义 并区分这两种类人猿亚型，对诊断和病人护理具有潜在的重要意义。

ABSTRACT Antiphosphatidylethanolamine (aPE) autoantibodies are associated with clinical symptoms of antiphospholipid syndrome (APS). However, the clinical significance of aPE remains to be fully established. In an effort to define aPE, we discovered that aPE actually consists of two distinctive subtypes. This notion is based on our findings that there are two types of aPE antibodies – cofactor-independent (aPEi) and cofactor-dependent (aPEd), which have different antigens and pathogenic mechanisms. In the current effort, we will investigate the clinical characteristics of aPE subtypes in a retrospective study by testing the hypothesis that aPEi and aPEd antibodies have different associations with the clinical and laboratory criteria for APS. The new knowledge will help define and differentiate the two subtypes of aPE, with potentially important implications on diagnosis and patient care.