EPHEDRINE NEPHROLITHIASIS FIRST CASE REPORT

麻黄素肾结石首例报告

• 批准号: 6486762
• 负责人: T POWELL
• 金额: $ 15.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6486762
• 关键词: biological products; biomedical resource; cardiovascular system; female; human subject; intestines; lipids; male; spectrometry

Ephedrine and its metabolites are naturally occurring alkaloids which can be derived from evergreens worldwide and have been used as medicinals for hundreds of years. Because they have pharmacological alpha and beta catecholamine effects and are natural products, the alternative medicine industry has popularized them for multiple uses including asthma, weight loss, energy and sexual enhancement, and euphoria. Several recent reviews have documented the dangerous nature of using these compounds unsupervised, including multiple deaths, and the FDA is currently reviewing ephedrine's use in the alternative medicine industry. We report a new toxicity, ephedrine nephrolithiasis, in a patient using an energy supplement, Ma-Huang extract, which contains ephedrine. Although previously not reported, the Louis C. Herring and Company kidney stone data base demonstrates that there is an endemic complication of ephedrine with hundreds of previous episodes. Using GC Mass Spectr ometry we were able to positively identify the chemical structure of our patients stone, as well as other similar stones from Louis Herring, as containing ephedrine, norephedrine, and pseudoephedrine.

麻黄碱及其代谢物为天然生物碱 可以从世界各地的常绿植物中提取，并已被用作 数百年来的医药行业。因为他们有药理作用 α-儿茶酚胺和β-儿茶酚胺都是天然产物， 替代医学行业已经普及了它们的多种用途 包括哮喘、减肥、能量和性功能增强，以及 欣快感。最近的几篇评论都记录了这种危险的性质 在无人监督的情况下使用这些化合物，包括多起死亡，以及 FDA目前正在审查麻黄素在替代药物中的使用 医药行业。我们报告了一种新的毒性，麻黄素 使用能量补充剂的患者患肾结石，麻黄 提取物，其中含有麻黄素。虽然之前没有报道， Louis C.Herring和公司肾结石数据库演示 有一种麻黄素的地方性并发症 之前的几集。利用气相色谱-质谱学技术 能够肯定地鉴定出我们的化学结构 病人石，以及来自路易·鲱鱼的其他类似结石， 含有麻黄素、去甲麻黄碱和伪麻黄碱。