EXCHANGE SCIENTIST IN MASS SPECTROMETRY

涉江博士在麻省理工学院进行为期六个月的学习 光谱分析资源从1998年5月开始。他的研究重点是 用质谱学技术研究DNA与药物的相互作用 修饰过的生物分子。具体地说，有两类药物处于 研究1)通过DNA沟槽结合的那些，和2)那些 通过DNA嵌入结合。质谱学将被用于 阐明受体-配体结合亲和力、配体结合部位 和配体结合选择性。

Dr. Shibue is on a six month study period at the Mass Spectrometry Resource starting in May of 1998. His research focuses on the DNA-drug interaction using mass spectrometric techniques and modified biomolecules. In particular, two types of drugs are under investigation 1) those which bind via DNA grooves, and 2) those which bind via DNA intercalation. Mass spectrometry will be used to elucidate receptor-ligand binding affinities, ligand binding sites, and ligand binding selectivities.