EXCHANGE SCIENTIST IN MASS SPECTROMETRY

Shibue博士正在马萨诸塞州进行为期六个月的研究 1998年5月开始的光谱资源。 他的研究重点 使用质谱技术研究DNA-药物相互作用， 修饰的生物分子。 特别是，有两种类型的药物在 研究1）通过DNA凹槽结合的那些，和2） 通过DNA嵌入结合。 质谱法将用于 阐明受体-配体结合亲和力，配体结合位点， 和配体结合选择性。

Dr. Shibue is on a six month study period at the Mass Spectrometry Resource starting in May of 1998. His research focuses on the DNA-drug interaction using mass spectrometric techniques and modified biomolecules. In particular, two types of drugs are under investigation 1) those which bind via DNA grooves, and 2) those which bind via DNA intercalation. Mass spectrometry will be used to elucidate receptor-ligand binding affinities, ligand binding sites, and ligand binding selectivities.