ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATION

巴西人口的抗氧化剂营养素

• 批准号: 6377134
• 负责人: Anna R. Giuliano
• 金额: $ 48.88万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-16 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6377134
• 关键词: Brazil; South American; blood chemistry; cancer risk; carotenoids; cervix neoplasms; clinical research; female; human papillomavirus; human subject; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; tocopherols; virus load; virus related neoplasm /cancer; women's health

DESCRIPTION (Adapted from the Applicant's Abstract): Epidemiologic research conducted over the past couple of decades has shown that infection with the human papilloma virus (HPV) is a cause of most cases of cervical cancer. Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased risk of developing CIN compared with women transiently infected. In addition, persistently HPV positive women appear to be four times more likely to have persistent cervical lesions. Although HPV infection is a cause of cervical cancer, it may be an insufficient cause requiring the presence of other factors for the infection to progress to a significant cervical lesion. Nutritional status may be an important cofactor affecting both HPV persistence and progression of persistent HPV infection to CIN. However, the association between nutritional status and cervical carcinogenesis has not been adequately tested. The overall goal of this application is to determine, using prospectively collected HPV and cytology data, the association between serum carotenoid and tocopherol status and cervical carcinogenesis among a cohort of high risk study participants in the Brazilian HPV Natural History Cohort (RO1 CA70269). This project will provide the first prospective analysis of serum carotenoid and tocopherol concentrations and risk for persistent HPV infection; it will be based on sensitive and specific methods for assessing type of HPV infection over a 12 month period, and evaluate subsequent 5 year risk of progression to CIN. This proposed study is unique in that if focuses on early events in cervical carcinogenesis: HPV infection, HPV persistence, and progression to CIN. It is cost-effective, utilizing previously collected serum samples and questionnaire data. The study utilizes state of the art methods for determining both PV status and serum carotenoid and tocopherol status. Furthermore, it incorporates multiple measurements of both HPV status and serum nutrient concentrations minimizing the probability that measurement imprecision resulting from temporal fluctuations will obscure the true association between nutrients status, and HPV persistence and risk of CIN. Results from this study will efficiently further our understanding of the role of antioxidant nutrients and cervical carcinogens.

描述（改编自申请人摘要）：流行病学研究 在过去的几十年里进行的研究表明， 人乳头瘤病毒（HPV）是大多数宫颈癌病例的原因。 前瞻性研究表明，感染HPV的女性更容易 宫颈上皮内瘤变（CIN），而那些 持续致癌型HPV感染的风险显著增加 与短暂感染的女性相比，此外，本发明还提供了一种方法， 持续HPV阳性的女性似乎有四倍以上的可能性， 持续性宫颈病变。 虽然HPV感染是宫颈癌的一个原因，但它可能是一个不充分的因素。 原因需要其他因素的存在，感染进展到 严重的宫颈病变营养状况可能是一个重要的辅助因素 影响HPV持续性和持续性HPV感染的进展， CIN。然而，营养状况与宫颈癌之间的关系 致癌作用尚未得到充分的测试。 本申请的总体目标是确定，前瞻性地使用 收集HPV和细胞学数据，血清类胡萝卜素和 高危人群生育酚水平与宫颈癌发生的关系 巴西HPV自然史队列（RO1 CA70269）的受试者。这 该项目将提供第一个血清类胡萝卜素的前瞻性分析， 生育酚浓度和持续性HPV感染的风险;它将是 基于评估HPV感染类型的敏感和特异性方法 在12个月的时间内，并评估随后5年进展至 CIN。这项拟议的研究是独特的，因为如果集中在早期事件， 宫颈癌发生：HPV感染、HPV持续存在和进展 中国。它具有成本效益，利用以前收集的血清样本， 问卷调查数据。该研究利用最先进的方法来确定 PV状态和血清类胡萝卜素和生育酚状态。而且 包括HPV状态和血清营养的多重测量 最大限度地降低测量不精确度 时间波动的结果将掩盖 营养状况、HPV持续性和CIN风险。本研究结果 将有效地促进我们对抗氧化营养素作用的理解， 和宫颈致癌物。