Arizona Alzheimer's Disease Core Center

描述（由申请人提供）： 该申请寻求五年的初步支持，以建立亚利桑那州 阿尔茨海默病核心中心（ADCC）。ADCC将提供 行政结构，领导，沟通，支持，临床和 组织病理学数据库需要帮助完成我们的科学使命， 整合我们的研究计划，促进我们的科学进步，并确保 我们的责任;它将与内外的研究人员密切合作 亚利桑那州，其他ADC和国家阿尔茨海默氏症协调中心（核心 A）。ADCC将帮助研究人员访问400个国家的数据并进行研究。 痴呆患者，80例轻度认知障碍（MCI）患者，以及 240名临床特征良好的正常老年对照受试者， 我们每年都会跟进，并参加我们的大脑捐赠计划;它将 每年评估这三组中的180名西班牙裔受试者， 探讨在6个美洲原住民国家进行研究的可行性， 它将提供一项独立研究中获得的数据， 认知正常的人没有副本，一个副本，两个副本， 载脂蛋白E4等位基因（Core B）。ADCC将提供组织病理学 在过期的大脑捐赠者和高质量的脑组织中进行诊断， 亚利桑那州内部和世界各地（核心C）。它将增加 通过教育，培训， 试点研究和合作研究;它将提高技能， AD和相关疾病患者的专业护理;它将教育 公众对AD和我们的ADCC的认识;它将提供创新的 西班牙裔和美洲原住民教育外展计划（核心D）。 亚利桑那州ADCC将进一步整合，协调和利用 资源和活动，在我们最近成立的，国家支持， 阿尔茨海默病研究中心（CADR）CADR的 主题是及早发现和预防阿尔茨海默病。其主要目标：（1） 检测和跟踪认知正常的痴呆和MCI患者的AD 具有AD遗传风险的人和使用脑成像的实验室动物 技术和其他研究方法;（2）帮助澄清某些AD 机制和危险因素;（3）进一步表征神经系统 涉及记忆、语言、情感和意识等方面， 它们所涉及的认知操作，以及它们在多大程度上 优先受AD和衰老的影响;（4）提供新的方法， 在人和实验室动物中研究AD和衰老的策略; (5)帮助确定治疗方法来阻止疾病的发展， AD的发病;（6）建立一个真正完整的，科学的 富有成效的“没有围墙的研究实验室”，作为一个模型， 多学科、多机构的研究。

DESCRIPTION (provided by applicant): This application seeks five years of initial support to establish the Arizona Alzheimer's Disease Core Center (ADCC). The ADCC will provide the administrative structure, leadership, communication, support, and clinical and histopathological database needed to help fulfill our scientific mission, integrate our research program, promote our scientific progress, and ensure our accountability; it will work closely with researchers inside and outside Arizona, other ADC's, and the National Alzheimer's Coordinating Center (Core A). The ADCC will help researchers access data from and conduct studies in 400 patients with dementia, 80 patients with mild cognitive impairment (MCI), and 240 normal elderly control subjects who are clinically well characterized, followed annually, and enrolled in our brain donation program; it will annually evaluate 180 additional Hispanic subjects in these three groups and explore the feasibility of conducting studies in 6 Native American Nations and Tribes; and it will provide access to data acquired in an independent study of cognitively normal persons with no copies, one copy, and two copies of the apolipoprotein E4 allele (Core B). The ADCC will provide histopathological diagnoses in expired brain donors and high-quality brain tissue to researchers inside Arizona and around the world (Core C). It will increase the number of productive scientists involved in AD research through education, training, pilot studies, and collaborative research; it will enhance skills for the professional care of patients with AD and related disorders; it will educate the general public about AD and our ADCC; and it will provide innovative Hispanic and Native American educational outreach programs (Core D). The Arizona ADCC will further integrate, coordinate, and capitalize on resources and activities in our recently established, state-supported, multi-institutional Center for Alzheimer's Disease Research (CADR). The CADR's major theme is the early detection and prevention of AD. Its major goals: (1) to detect and track AD in patients with dementia and MCI, cognitively normal persons at genetic risk for AD, and laboratory animals using brain imaging techniques and other research methods; (2) to help clarify certain AD mechanisms and risk factors; (3) to further characterize the neural systems involved in aspects of memory, language, emotion, and consciousness, the cognitive operations to which they are related, and the extent to which they are preferentially affected by AD and aging; (4) to provide new methods and strategies for the study of AD and aging in persons and laboratory animals; (5) to help identify treatments to halt the progression and, indeed, prevent the onset of AD; and (6) to establish a truly integrated, scientifically productive "research laboratory without walls," which serves as a model of multi-disciplinary, multi-institutional research.