Neuropathology Core

神经病理学核心是阿尔茨海默病核心中心（ADCC）的重要组成部分。在生活中，阿尔茨海默病（AD）的体征和症状与其他几种疾病没有足够的不同，导致误诊，即使在最先进的中心，约25%的受试者。因此，由经过认证的神经病理学家在死后对大脑进行检查是唯一的方法， 可以得到明确的诊断，使所有的研究结果得到正确的解释。神经病理学核心的第二个主要作用是为ADCC内外的基础科学家提供神经病理学特征的脑组织，使他们能够发现疾病的潜在分子机制并设计适当的治疗干预措施。通过对患病和非患病脑组织的比较研究，详细了解疾病发病机制的遗传和分子过程，仍然是找到这种干预措施的主要方法。神经病理学核心的第三个重要目标是帮助发展一种合作的协同作用，这将加强研究 整个中心的生产力。我们的具体目标如下：1）为临床中心临床研究的患者提供精确的神经病理学诊断。2)为基础科学家提供神经病理学特征的脑组织，适用于阐明AD和相关疾病的分子机制，特别是帮助研究人员研究阿尔茨海默病的早期阶段，目的是确定预防疾病或减缓其进展的治疗策略。3)与所有ADCC研究人员和科学界分享神经病理学技能，专业知识，知识和数据，促进协作协同作用，提高所有人的研究生产力。

The Neuropathology Core is an essential part of the Alzheimer's Disease Core Center (ADCC). During life, the signs and symptoms of Alzheimer's disease (AD) are not sufficiently different from several other conditions, resulting in misdiagnosis, even at the most advanced centers, in about 25% of subjects. Examination of the brain after death by a certified Neuropathologist is therefore the only means by which a definite diagnosis can be attained, allowing all research results to be correctly interpreted. A second major role of the Neuropathology Core is to provide neuropathologically characterized brain tissue to basic scientists, both within the ADCC and outside it, enabling them to discover the underlying molecular mechanisms of disease and design appropriate therapeutic interventions. A detailed understanding of the genetic and molecular processes of disease pathogenesis, obtained by comparative study of diseased and non-diseased brain tissue, remains the major approach to finding such interventions. A third important goal of the Neuropathology Core is to help develop a collaborative synergy that will enhance the research productivity of the entire Center. Our Specific Aims are as follows: 1)To provide precise neuropathoiogic diagnoses of patients that have been clinically studied by the Cinical Core. 2) To provide basic scientists with neuropathologically characterized brain tissue suitable for the elucidation of the molecular mechanisms of AD and related disorders, and especially to assist researchers in their studies of the earliest stages of Alzheimer's disease, with the goal of identifying therapeutic strategies that will prevent the disease or slow its progress. 3) To share neuropathological skills, expertise, knowledge and data with all ADCC investigators and the scientific community at large, facilitating a collaborative synergy that will enhance the research productivity of all.