Arizona Alzheimer's Disease Core Center

描述（由申请人提供）：本赠款申请要求为亚利桑那州阿尔茨海默病核心中心（ADCC）提供五年的新支持。ADCC旨在优化其核心的开发和使用，以便利用亚利桑那州的科学和组织资源来了解，早期检测和跟踪阿尔茨海默病（AD）以及发现疾病减缓和预防疗法。从理论上讲，ADCC的目的是建立一个领先的模式，全州合作的AD研究。 行政核心提供优化其核心的开发、互动和使用所需的领导和支持。它与亚利桑那州内外的研究人员，国家阿尔茨海默氏症协调中心（NACC）和其他AD中心密切合作，促进AD相关研究和合作的发展和进步。它管理着一个全州范围内的征集，竞争性审查和支持试点研究的计划。它有助于解决挑战和履行与ADCC全州合作模式相关的机会，并确保ADCC对NIA的责任。 临床核心维护了大量临床表征良好并每年评估的研究受试者，用于AD和衰老的科学研究。这些受试者包括AD和其他痴呆症患者、轻度认知障碍（MCI）患者和正常对照组，几乎所有人都参加了大脑捐赠计划，以及越来越多的拉丁裔和美洲印第安人研究受试者。该核心确保了其五个临床研究中心的受试者和数据的可比性、有效性和适当使用。它还促进了生产和适当的科学使用纵向跟踪的主题，DNA和数据从三个独立资助的辅助程序，产生新的信息从认知正常老化的人在不同的AD风险认知下降的过渡。 数据管理和统计核心维护ADCC的数据库，帮助确保数据的质量和保护受试者的机密性，并以最适合全州ADCC需求的方式提供统计服务。它与研究人员，NACC和其他AD中心密切合作，以最有效，及时和适当的方式共享数据。 神经病理学核心提供神经病理学诊断和非常高质量的脑组织从过期的临床核心科目，以支持在亚利桑那州和世界各地的研究。它还促进了从其独立资助的辅助脑捐赠计划中获得的大量临床和神经病理学特征良好的非痴呆老年受试者的生物材料的生产和适当使用，帮助解决AD研究界的关键需求。 教育和信息核心提供培训，创新的教育和推广计划，以及战略合作伙伴关系，以促进AD相关研究人员的发展，满足专业和家庭护理人员的需求，提供有关ADCC的信息，并解决亚利桑那州的美国印第安人和快速增长的拉丁裔社区未满足的需求。

DESCRIPTION (provided by applicant): This grant application requests five years of renewed support for the Arizona Alzheimer's Disease Core Center (ADCC). Scientifically, the ADCC is intended to optimize the development and use of its Cores, so as to capitalize on Arizona's scientific and organizational resources in the understanding, very early detection, and tracking of Alzheimer's disease (AD) and in the discovery of disease-slowing and prevention therapies. Organizationally, the ADCC is intended to establish a leading model of statewide collaboration in AD research. The Administrative Core provides the leadership and support needed to optimize the development, interaction, and use of its Cores. Working closely with researchers inside and outside Arizona, the National Alzheimer's Coordinating Center (NACC), and other AD Centers, it promotes the development and progress of AD-related studies and collaborations. It administers a program for the statewide solicitation, competitive review, and support of pilot studies. It helps solve the challenges and fulfill the opportunities associated with the ADCCs statewide collaborative model, and ensures the ADCC's accountability to the NIA. The Clinical Core maintains a large pool of clinically well characterized and annually assessed research subjects for the scientific study of AD and aging. The subjects include patients with AD and other dementias, patients with mild cognitive impairment (MCI), and normal controls, almost all of whom are enrolled in a brain donation program, and a growing pool of Latino and American Indian research subjects. This Core ensures the comparability and productive and appropriate use of subjects and data from its five clinical sites. It also promotes the productive and appropriate scientific use of longitudinally followed subjects, DNA, and data from three independently funded ancillary programs, yielding new information about the transition from cognitively normal aging to cognitive decline in persons at differential risk for AD. The Data Management and Statistics Core maintains the ADCC's database, helps ensure the quality of data and the protection of subject confidentiality, and provides statistical services in a manner that best serves the needs of the statewide ADCC. It works closely with researchers, NACC, and other AD Centers, sharing data in the most productive, timely, and appropriate way. The Neuropathology Core provides neuropathological diagnoses and extremely high-quality brain tissue from expired Clinical Core subjects to support research studies in Arizona and around the world. It also promotes the productive and appropriate use of biological materials from a large additional number of clinically and neuropathologically well characterized non-demented elderly subjects from its independently funded ancillary brain donation program, helping to address a critical need in the AD research community. The Education and Information Core provides training, innovative educational and outreach programs, and strategic partnerships to promote the development of AD-related researchers, address needs of professional and family caregivers, provide information about the ADCC, and address unmet needs of Arizona's American Indian and rapidly growing Latino communities.