Cyclotron, PET and MRI Facility Improvement: A Scientific Resource for Arizona

回旋加速器、PET 和 MRI 设施改进：​​亚利桑那州的科学资源

• 批准号: 7898499
• 负责人: ERIC MICHAEL REIMAN
• 金额: $ 653.02万
• 依托单位: BANNER ALZHEIMER'S INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898499
• 关键词: 20 year old; Alzheimer' s Disease; Arizona; Biomedical Research; Brain imaging; Cancer Center; Clinical Trials; Communication; Cyclotrons; Detection; Development; Devices; Diabetes Mellitus; Disease; Environment; Equipment; Evaluation; Funding; Future; General Population; Growth; Health; Hospitals; Image; Image Analysis; Imaging Device; Imaging Techniques; Institutes; Institution; Investments; Laboratories; Lead; Leadership; Longitudinal Studies; Magnetic Resonance Imaging; Methods; Obesity; Occupations; Participant; Positron-Emission Tomography; Productivity; Quality Control; Radioactive; Radiochemistry; Request for Applications; Research; Research Institute; Research Personnel; Resources; Role; Safety; Schedule; Security Measures; System; Technology; The Sun; Tracer; Universities; age related; base; catalyst; design; improved; meetings; normal aging; novel; oncology; programs; research and development; research study; square foot

DESCRIPTION (provided by applicant): This application requests funds for the renovation of existing space as well as for a small building addition that will allow us to relocate and expand our nearly 20 year old cyclotron and radiochemistry laboratory, Positron Emission Tomography (PET) imaging and computational image-analysis suites as well as provide future space for Magnetic Resonance Imaging (MRI) and an additional PET system. The urgent need for this request is due to the significant inadequacy of the current cyclotron and radiochemistry facility, not only in meeting current and pending manufacturing requirements, but also in meeting investigator demand for new PET tracers. Banner Health was one of the first non-university based hospital systems to purchase a cyclotron. Its PET Center became a leader in brain-imaging research, a resource to researchers throughout Arizona and a major catalyst to the development of the Banner Alzheimer's Institute (BAI), Arizona Alzheimer's Consortium, and Arizona Bioscience Roadmap. We plan to renovate the new facility to centralize these activities, purchase additional built-in radiochemistry equipment, and increase our total laboratory space from 6,378 to 16,520 gross square feet (GSF) to support our rapidly growing research needs. Research control of imaging devices, such as the PET and proposed MRI allows us to assure rigorous quality control and the avoidance of elective hardware changes that might reduce statistical power or introduce confounds in longitudinal studies and long clinical trials, greatly increasing MRI research productivity. The renovated facility permits us to expand our research programs at the BAI, as well as Banner's recently acquired Sun Health Research Institute, and will catalyze the development of research in the recently approved MD Anderson Banner Cancer Center, and other institutions in the state. It would maximize communication among radiochemistry, PET, MRI and scientific researchers and improve research participant scheduling, convenience, and throughput in our various research studies. The facility improvement will lead to significant new biomedical research investments at Banner Health and other Arizona institutions, provide a vital statewide scientific resource, as well as maintain and create jobs. The proposed design improves the quality of the environment by utilizing green technology and enhances safety for staff and the general public through specialized security measures and novel radioactive control devices. Shell space built as a part of this application will allow for growth of the imaging center. The need for a second PET research scanner is anticipated within 3 years while the need for a dedicated research MRI scanner is imminent. It would galvanize PET and MRI research in Alzheimer's disease, oncology, obesity, diabetes, as well as age-related disorders and normal aging, and the development of new image-acquisition and image-analysis methods. Specifically, to Alzheimer's disease the facility would permit us to maintain and enhance our leadership role in the application of brain-imaging techniques to pre-symptomatic study, detection, and tracking of Alzheimer's disease and the evaluation of disease-slowing treatments.

描述（由申请人提供）：本申请要求进行现有空间的翻新以及一个小型建筑物的补充，这将使我们能够重新安置和扩展我们将近20岁的回旋和放射化学实验室，正电子发射层析成像（PET）成像和计算图像 - 分析套件，并为磁性共振成像（MRI）和其他PET系统提供未来的空间。对此要求的迫切需求是由于当前的回旋和放射化学设施的严重不足，不仅在满足当前和未决的制造要求上，而且还满足了调查员对新宠物示踪剂的需求。 Banner Health是最早基于非大学的医院系统之一。它的宠物中心成为大脑成像研究的领导者，是亚利桑那州的研究人员的资源，也是对旗帜阿尔茨海默氏症研究所（BAI），亚利桑那州阿尔茨海默氏症联盟和亚利桑那生物科学路线图发展的主要催化剂的资源。我们计划翻新新设施，以集中这些活动，购买额外的内置放射化学设备，并将我们的总实验室空间从6,378增加到16,520平方英尺（GSF），以支持我们快速增长的研究需求。对成像设备的研究控制，例如PET和提议的MRI，使我们能够确保严格的质量控制以及避免选择性硬件变化，从而在纵向研究和长期临床试验中降低统计能力或引入混杂，从而大大提高了MRI研究生产力。经过翻新的设施使我们能够在BAI以及最近收购的Sun Health Research Institute扩大研究计划，并将促进最近批准的MD Anderson Banner癌症中心和该州的其他机构的研究发展。它将在我们的各种研究中最大程度地提高放射化学，宠物，MRI和科学研究人员之间的沟通，并改善研究参与者的日程安排，便利性和吞吐量。该设施的改进将导致Banner Health和其他亚利桑那机构的新生物医学研究投资，提供至关重要的全州科学资源，并维护和创造就业机会。拟议的设计通过利用绿色技术并通过专门的安全措施和新颖的放射性控制设备来提高员工和公众的安全来提高环境的质量。作为此应用程序的一部分建造的壳空间将允许成像中心的增长。预计需要第二次宠物研究扫描仪的需求将在3年内进行，而对MRI扫描仪的需求迫在眉睫。它将在阿尔茨海默氏病，肿瘤学，肥胖，糖尿病以及与年龄有关的疾病和正常衰老以及新的图像学和图像分析方法的发展中激发宠物和MRI研究。具体而言，对于阿尔茨海默氏病，该设施将使我们能够维持和增强我们在脑成像技术的应用中的领导作用，并在症状前研究，检测和跟踪阿尔茨海默氏病以及评估缓慢疾病的治疗方面。