The GE PETtrace Cyclotron: A Scientific Resource for the State of Arizona

描述（由申请人提供）：Banner Health是第一家购买回旋加速器的非大学医疗机构。由此产生的PET中心成为脑成像研究的领导者，是整个亚利桑那州研究人员的资源，也是亚利桑那州阿尔茨海默氏症联盟和亚利桑那州生物科学路线图发展的主要催化剂。它将多个科学学科的领导者引入脑成像研究，并在不同机构的研究人员之间建立了牢固的关系。它在记忆、意识、情感、温度和疼痛感觉、饥饿、饱腹感、味觉和肥胖易感性的研究、PET在临床肿瘤学中的作用、脑成像在神经外科治疗计划中的作用、脑成像在科学研究中的作用、异常早期检测和跟踪、阿尔茨海默病的治疗和预防、多学科研究人员的培训等方面做出了重大贡献。以及新的图像采集和图像分析技术的发展。随着我们老化回旋加速器更换部件的停止，迫切需要一个新的回旋加速器系统来支持正在进行的研究项目，并利用班纳健康和全州的新科学机会。我们请求资金购买GE PETtrace回旋加速器系统，以取代我们老化的回旋加速器，确保我们著名的研究项目不间断地继续进行，利用并为Banner Health和其他亚利桑那州机构的重大新生物医学研究投资提供基础，并提供重要的全州科学资源。这种共享的科学资源将允许亚利桑那州和周边各州的研究人员利用班纳健康的PET和PET/CT系统，计划收购移动微型PET系统作为全州动物成像资源，最近成立的班纳阿尔茨海默病研究所（BAI）和MD安德森班纳癌症中心（MDA）。它将利用BAI、MDA、太阳健康研究所、转化基因组学研究所（TGen）、亚利桑那州立大学、亚利桑那大学、亚利桑那州梅奥诊所、巴罗神经学研究所、圣约瑟夫医疗中心和斯科茨代尔医疗中心的现有研究项目和重大新投资。新的回旋加速器系统将激发与阿尔茨海默病、认知、行为和临床神经科学、肿瘤学、肥胖、糖尿病和其他疾病相关的研究，并开发新的图像采集和图像分析方法。它将解决我们迫切需要替换老化和过时的回旋加速器的问题。它将使我们能够扩大我们的放射化学资源，满足整个亚利桑那州研究人员快速增长的需求，并为班纳和全州的PET研究提供一系列放射性示踪剂。除此之外，亚利桑那州有一个前所未有的机会来利用这些设备进行癌症研究，加速评估有前途的阿尔茨海默氏症预防疗法，并维持和创造新的就业机会。

DESCRIPTION (provided by applicant): Banner Health was the first non-university based healthcare organization to purchase a cyclotron. The resulting PET Center became a leader in brain-imaging research, a resource to researchers throughout Arizona, and a major catalyst to the development of both the Arizona Alzheimer's Consortium and the Arizona Bioscience Roadmap. It introduced leaders from several scientific disciplines to brain-imaging research and forged strong relationships among researchers from different institutions. It made major contributions to the study of memory, consciousness, emotion, temperature and pain sensation, hunger, satiation, taste and the predisposition to obesity, the role of PET in clinical oncology, the role of brain-mapping in neurosurgical treatment planning, the role of brain imaging in the scientific study, unusually early detection and tracking, treatment and prevention of Alzheimer's disease, the training of researchers from multiple scientific disciplines, and the development of new image-acquisition and image-analysis techniques. With the cessation of replacement parts for our aging cyclotron, a new cyclotron system is critically needed to support ongoing research programs and capitalize on new scientific opportunities at Banner Health and around the state. We request the funds to purchase the GE PETtrace cyclotron system to replace our aging cyclotron, ensure uninterrupted continuation of our well-known research program, capitalize on and provide a foundation for significant new biomedical research investments at Banner Health and other Arizona institutions, and provide a vital statewide scientific resource. This shared scientific resource will permit researchers in Arizona and in surrounding states to capitalize on PET and PET/CT systems at Banner Health, the planned acquisition of a mobile micro-PET system as a statewide animal-imaging resource, the recently established Banner Alzheimer's Institute (BAI) and recently established MD Anderson Banner Cancer Center (MDA). It will capitalize on existing research programs and major new investments at the BAI, MDA, Sun Health Research Institute, Translational Genomics Research Institute (TGen), Arizona State University, University of Arizona, Mayo Clinic Arizona, Barrow Neurological Institute, St. Joseph's Medical Center and Scottsdale Healthcare. The new cyclotron system will galvanize research related to Alzheimer's disease, the cognitive, behavioral and clinical neurosciences, oncology, obesity, diabetes, other disorders, and the development of new image- acquisition and image-analysis methods. It will address our urgent need to replace our aging and now obsolete cyclotron. It will permit us to expand our radiochemistry resources, address the rapidly growing needs of researchers throughout Arizona, and provide a range of radiotracers for PET research studies at Banner and around the state. Among other things, Arizona has an unprecedented opportunity to leverage this equipment in cancer research, the accelerated evaluation of promising Alzheimer's prevention therapies, and both the maintenance and creation of new jobs. PUBLIC HEALTH RELEVANCE: The GE PETtrace cyclotron will provide a rare, valuable resource to researchers throughout Arizona. It will make major contributions to the understanding of the living human brain, the fight against Alzheimer's disease, cancer, and other medical disorders, and the development of improved imaging methods. This resource will help us to create 3 new jobs and maintain about 21 existing positions at Banner Health while generating or maintaining more than 27 jobs within the Phoenix metropolitan area, and promote major investments in biomedical research throughout Arizona.