CELL SURFACE PROTEIN INTERACTIONS IN NEURODEVELOPMENT

描述（根据申请人的描述改编）：该计划研究发育中的神经细胞识别，翻译和响应细胞外信号的细胞和分子机制。每个参与计划的实验室检查神经细胞与其环境的不同相互作用的功能和分子机制，包括轴突识别，突触形成，可塑性和少突胶质细胞前体迁移。具体而言，钙粘蛋白，受体型，酪氨酸激酶的Eph家族和他们的肝配蛋白配体，和膜结合蛋白聚糖的功能和运作机制将进行研究。Ranscht博士的项目使用T-钙粘蛋白功能被破坏的小鼠来检查T-钙粘蛋白在海马体中轴突通路识别和突触形成中的作用。Yamaguchi博士的项目解决了蛋白聚糖syndecan-2在海马神经元树突棘成熟中的功能Pasquale博士的项目研究了Ephbeta 2及其ephrin-B1配体的双向信号传导机制，这是一种在海马突触中表达的受体配体对。Stallcup博士的项目确定了蛋白聚糖NG 2信号少突胶质细胞前体细胞迁移的机制。

DESCRIPTION (Adapted from applicant's description): This program investigates the cellular and molecular mechanisms by which developing neural cells recognize, translate and respond to extracellular signals. Each of the participating Program laboratories examines the function and molecular mechanisms underlying distinct interactions of neural cells with their environment, including axonal recognition, synapse formation, plasticity, and oligodendrocyte precursor migration. Specifically, the functions and mechanisms of operation of cadherin, receptor-type, tyrosine kinases of the Eph-family and their ephrin-ligands, and membrane-bound proteoglycans will be investigated. Dr. Ranscht's project examines the role of T-cadherin in axonal pathway recognition and synapse formation in the hippocampus using mice with disrupted T- cadherin function. Dr. Yamaguchi's project addresses the function of proteoglycan syndecan-2 in dendritic spine maturation of hippocampal neurons Dr. Pasquale's project investigates the bi-directional signaling mechanisms of Ephbeta2 and its ephrin-B1 ligand, a receptor ligand pair that is expressed in hippocampal synapses. Dr. Stallcup's project determines the mechanism by which proteoglycan NG2 signals oligodendrocyte precursor cells to migrate.