Role of T-Cadherin in Adiponection-mediated cardiovascular functions

T-钙粘蛋白在脂肪连接介导的心血管功能中的作用

基本信息

项目摘要

DESCRIPTION (provided by applicant): Obesity-related metabolic syndrome is major risk factor for cardiovascular diseases. Adiponectin (APN), a circulating fat-secreted cytokine, is implicated in protecting against obesity-related metabolic and cardiovascular dysfunctions. Levels of APN decrease with the expansion of adipose tissue and low levels are associated with coronary artery disease, hypertension, heart infarct and other cardiovascular dysfunctions. In animal models of cardiac hypertrophy and ischemic heart disease, administration of APN improves pathological myocardial remodeling. While the beneficial functions of APN are well described, little is known about membrane receptors that enable APN's physiological functions in the cardiovascular system. T-cadherin, an APN binding protein implicated by genetic linkage analysis in cardiovascular functions, is a candidate cell surface glycoprotein to mediate APN functions. This R21 application will explore the functions of T-cadherin in a mouse model of heart disease and relate a potential role to the functions of adiponectin. PUBLIC HEALTH RELEVANCE: Obesity contributes to metabolic and cardiovascular disorders by altering the levels of adipocyte-secreted pro- and anti-inflammatory cytokines in the circulation. Adiponectin is a fat-secreted anti-inflammatory cytokine with beneficial actions in regulating metabolic and cardiovascular functions. Adiponectin associates with cardiomyocyte and endothelial cell surfaces to exert beneficial functions. The receptors that enable the engagement of adiponectin with cell surfaces and lead to activation of downstream signaling cascades remain poorly understood. Research proposed in this application will explore the contributions of T- cadherin, a novel adiponectin-binding cell surface glycoprotein, in functions of the heart and vasculature. Specifically, the proposed experiments will test if T-cadherin is essential for the cardioprotective actions of adiponectin. This work will contribute to understanding adiponectin's cardiovascular-protective functions and - if successful - form a new basis for exploring the T-cadherin-adiponectin interaction as a possible drug target for recovery from cardiovascular injury.
描述(由申请人提供):肥胖相关代谢综合征是心血管疾病的主要危险因素。脂联素(APN)是一种循环脂肪分泌的细胞因子,与预防肥胖相关的代谢和心血管功能障碍有关。APN水平随着脂肪组织的扩张而降低,低水平与冠状动脉疾病、高血压、心脏梗死和其他心血管功能障碍有关。在心肌肥厚和缺血性心脏病动物模型中,APN可改善病理性心肌重构。虽然APN的有益功能已被很好地描述,但对使APN在心血管系统中发挥生理功能的膜受体知之甚少。t -钙粘蛋白(T-cadherin)是一种介导APN功能的候选细胞表面糖蛋白,与心血管功能的遗传连锁分析有关。这个R21应用程序将探索t -钙粘蛋白在心脏病小鼠模型中的功能,并将其与脂联素的功能联系起来。

项目成果

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BARBARA RANSCHT其他文献

BARBARA RANSCHT的其他文献

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{{ truncateString('BARBARA RANSCHT', 18)}}的其他基金

Adiponectin Functions in Hippocampus
脂联素在海马中的功能
  • 批准号:
    8685062
  • 财政年份:
    2014
  • 资助金额:
    $ 28.65万
  • 项目类别:
Adiponectin Functions in Hippocampus
脂联素在海马中的功能
  • 批准号:
    8831009
  • 财政年份:
    2014
  • 资助金额:
    $ 28.65万
  • 项目类别:
CELL IMAGING AND HISTOPATHOLOGY
细胞成像和组织病理学
  • 批准号:
    8378391
  • 财政年份:
    2012
  • 资助金额:
    $ 28.65万
  • 项目类别:
Role of T-Cadherin in Adiponection-mediated cardiovascular functions
T-钙粘蛋白在脂肪连接介导的心血管功能中的作用
  • 批准号:
    8055538
  • 财政年份:
    2010
  • 资助金额:
    $ 28.65万
  • 项目类别:
Neural Cell Culture and Electrophysiology
神经细胞培养和电生理学
  • 批准号:
    8056779
  • 财政年份:
    2010
  • 资助金额:
    $ 28.65万
  • 项目类别:
CELL IMAGING AND HISTOPATHOLOGY
细胞成像和组织病理学
  • 批准号:
    8181802
  • 财政年份:
    2010
  • 资助金额:
    $ 28.65万
  • 项目类别:
Tissue Culture
组织培养
  • 批准号:
    7185426
  • 财政年份:
    2006
  • 资助金额:
    $ 28.65万
  • 项目类别:
CORE--Shared Resources Cell Imaging and Histology
CORE--共享资源细胞成像和组织学
  • 批准号:
    6990465
  • 财政年份:
    2004
  • 资助金额:
    $ 28.65万
  • 项目类别:
Cadherin mediated interactions in the hippocampus
钙粘蛋白介导的海马相互作用
  • 批准号:
    6583736
  • 财政年份:
    2002
  • 资助金额:
    $ 28.65万
  • 项目类别:
Core--Tissue culture
核心--组织培养
  • 批准号:
    6583740
  • 财政年份:
    2002
  • 资助金额:
    $ 28.65万
  • 项目类别:

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成纤维细胞生长因子 8b 将棕色脂肪细胞募集到内脏白色脂肪组织中
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