Why do some polyphenols reduce atherosclerosis but others not? (KROON_F17DTP)

为什么有些多酚可以减少动脉粥样硬化，而另一些则不能？

• 批准号: 1937498
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1937498
• 关键词: Why; do; some; polyphenols; reduce

Regular consumption of certain polyphenols which are found in plant foods have been shown to cause beneficial changes in biomarkers of health, particularly cardiovascular health. We recently have shown that feeding tomatoes expressing polyphenols such as resveratrol or anthocyanins to mice which had ApoE knocked out (to mimic high circulating cholesterol phenotype) for 17 weeks significantly reduced plaque size while other polyphenols such as flavonols or isoflavones had no effect on plaque size. We therefore aim to investigate the effects of the different polyphenols on lipid and lipoprotein metabolism and gene expression profiles and attempt to associate these changes with the polyphenol metabolites generated from each diet.

经常食用植物性食物中发现的某些多酚已被证明会导致健康生物标志物的有益变化，特别是心血管健康。我们最近已经表明，将表达多酚如白藜芦醇或花青素的番茄喂给ApoE敲除（以模拟高循环胆固醇表型）的小鼠17周，显着降低了斑块大小，而其他多酚如黄酮醇或异黄酮对斑块大小没有影响。因此，我们的目的是调查不同的多酚对脂质和脂蛋白代谢和基因表达谱的影响，并试图将这些变化与每种饮食产生的多酚代谢产物联系起来。

项目成果

No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo-Controlled, Cross-Over Trial.

• DOI: 10.1002/mnfr.202101157
• 发表时间: 2022-11
• 期刊: Molecular nutrition & food research
• 影响因子: 5.2