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In vitro and in vivo vascular response to exercise and supplement induced changes in blood flow

体外和体内血管对运动和补充剂引起的血流变化的反应

基本信息

批准号：
1943514
负责人：
金额：
--
依托单位：
University of Birmingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1943514
关键词：
vitro vivo vascular response exercise

项目摘要

Vascular health is a key component to many of the most significant health problems in the western world, including stroke, coronary artery disease, hypertension and diabetes, as well as being central to the aging process. Commonly poor vascular health and dysfunction are treated clinically using targeted medication, however, increasingly there is a drive to improve the health and diet of the population through lifestyle interventions, to prevent or delay decline and as an adjunct treatment to classical medicinal approaches. This had led to recent increases in research into the specific impact of physical activity on the vascular system, in order to better understand the impact that physical activity outside of the exercising muscle and to optimise current guidelines to maximise the benefits of regular physical activity. Recently it has been suggested that different exercise types and intensities of exercise can have a differential effect on peripheral and cerebral vascular function, due to the changes in oxygen demand and alterations in blood flow distribution. Changes in blood flow have a significant impact on the signalling and adaptive response seen in the vascular system, due to changes in shear stress which are essential to endothelial response, however, the impact that these changes have on cellular signalling and other markers of function and health is not well understood. For this reason, this project will aim to determine the impact of different exercise formats on cerebral and peripheral vascular function, as well as in the profile of a range of signalling, inflammatory and endothelial function markers within the blood. Additionally, in order to investigate the effects of different resting and exercising blood flow patterns, we aim to develop a controllable shear stress cell culture model, which can be used to simulate exercise-induced changes in shear stress to better understand the cellular impact of these changes.

血管健康是西方世界许多最重要的健康问题的关键组成部分，包括中风、冠状动脉疾病、高血压和糖尿病，也是老龄化过程的核心。通常情况下，血管健康状况不佳和功能障碍的治疗通常使用靶向药物治疗，然而，越来越多的人希望通过生活方式干预来改善人群的健康和饮食，以防止或延缓衰退，并作为传统医学方法的辅助治疗。这导致了最近关于体育活动对血管系统具体影响的研究增加，以便更好地了解锻炼肌肉以外的体育活动的影响，并优化目前的指导方针，以最大限度地发挥定期体育活动的好处。最近有研究表明，不同的运动类型和强度对周围血管和脑血管功能的影响是不同的，这是由于氧需求的变化和血流分布的改变。血流的变化对血管系统中的信号和适应性反应有重大影响，这是由于切应力的变化是内皮反应的关键，然而，这些变化对细胞信号和其他功能和健康标记物的影响尚不清楚。为此，该项目旨在确定不同运动形式对大脑和外周血管功能的影响，以及血液中一系列信号、炎症和内皮功能标记物的影响。此外，为了研究不同静息和运动血流模式的影响，我们的目标是开发一种可控制的剪应力细胞培养模型，该模型可以用来模拟运动诱导的剪应力变化，以更好地了解这些变化对细胞的影响。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise.

脑血液动力学和神经营养因子反应取决于运动类型。

DOI：
10.3389/fphys.2020.609935
发表时间：
2020
期刊：
Frontiers in physiology
影响因子：
4
作者：
Weaver SR;Skinner BD;Furlong R;Lucas RAI;Cable NT;Rendeiro C;McGettrick HM;Lucas SJE
通讯作者：
Lucas SJE

Non-pharmacological interventions for vascular health and the role of the endothelium.