CORE--LABORATORY ANIMALS

基底神经节研究中心实验动物中心作为一个 促进、丰富和协调动物模型的共享资源 为六个组成项目中的五个进行研究。 这个核心有，超过 以前的赠款和项目期间，开发和维护的障碍- 持续的，无疾病的神经模型大鼠和小鼠的殖民地， 为了减少影响新的和正在进行的动物变量的数据 问题研究 我们从所有的实验群体中清除了传染源， 建造和翻新了新的障碍住房区，建立了一个 有效的健康监测方案，设计和建立改进的 行为模拟研究动物的饲养环境条件 行为测试实验室与动物饲养室相邻， 建立了一个无病的日本亚种新繁殖群 Fisher-344无胸腺裸大鼠用于同种异体和人神经组织 在这个中心进行异种移植研究。 实验动物中心将继续 为了促进先前开发的动物模型研究的所有方面， 并切实贯彻 此外，核心主任将制定一个新的， 自动化数据库，将包括，监测和跟踪所有实验 所有项目中使用的动物。 所有项目动物都将是独一无二的 用电子芯片识别 该数据库将 与所有中心研究者联网并可访问。 芯会 协调项目内部和项目之间所有动物的使用， 最大限度地提高动物使用效率， 不必要和多余的动物使用。 此外，核心直接或将 大大扩展了他对个人项目研究的参与。

The Basal Ganglion Research Center Laboratory Animal Core operates as a shared resource which facilitates, enriches and coordinates animal model studies for five of the six component projects. This core has, over previous grant and project periods, developed and maintained barrier- sustained, disease-free colonies of neurologically modeled rats and mice in order to reduce data compromising animal variables for new and ongoing studies. We eliminated infectious agents from all experimental colonies, constructed and renovated new barriered housing areas, established an effective health surveillance program, designed and established improved environmental conditions for housing behavioral modeled research animals with behavioral testing laboratories contiguous to animal housing rooms and established a disease free, new breeding colony of Japanese substrain Fisher-344 athymic nude rats for use in allo- and human neural tissue xenograft studies in this Center. The laboratory Animal Core will continue to facilitate all aspects of animal model studies as previously developed and implemented. In addition, the Core Director will develop a new, automated data base which will include, monitor and track all experimental animals used in all projects. All project animals will be uniquely identified with electronic, transponder microchips. This data base will be networked to and be accessible by all Center investigators. The Core will coordinate the use of all animals within and between projects in order to maximize the efficiency of animal use and eliminate any potential unnecessary and redundant animal use. In addition, the Core Direct or will significantly expand his involvement in individual project research.