CORE--Molecular genetics and environmental carcinogenesis

核心--分子遗传学与环境致癌

• 批准号: 6442960
• 负责人: Cheryl L. Walker
• 金额: $ 11.79万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6442960
• 关键词: biomedical facility; chemical carcinogenesis; environment related neoplasm /cancer; environmental exposure; environmental health; environmental toxicology; genetic susceptibility; molecular genetics; molecular oncology

Description: This core is directed by Dr. Cheryl Walker and consists of 15 members, four which hold secondary appoints in the core. Two of the primary members are Associate Members of the Center while one is an Affiliate Member. Since the last review, at which time this core was entitled, "Impact of Environmental Agents on Cell Growth and Differentiation", three members have left the institution, one changed his affiliation from Core 3 to Core 1, one membership was terminated due to a lack of participation, and three individuals appear to have been recruited as new members. The goal of this core is to foster interactive research between CRED investigators to define cellular and molecular responses to environmental exposures and identify the genetic basis for variability in those responses. To accomplish this goal, four specific aims are proposed: 1) to serve as a catalyst for multidisciplinary, collaborative research between CRED investigators in the areas of genetic susceptibility, use of genetically defined animal models, and emerging molecular technologies; 2) to support core research efforts through interactive discussion forums, sponsorship of outside seminar speakers, and pilot projects; 3) to promote the advancement of junior faculty and encourage the recruitment of individuals into the center who would interact with this Core?s activities; and 4) To serve as a voice for the interests of Core 3 members within the larger CRED and as a conduit for contribution of unique Core 3 expertise to the Center. The Molecular Genetics and Environmental Carcinogenesis Core holds 2.8 million dollars in current grant support (0.34 million in NIEHS support) with an additional 1.0 million pending. Several of the existing and pending grant applications involve new collaborative efforts. In addition, a new program project grant has recently been awarded to one of the Core 3 investigators that also involves others from the core and Center. Research Core 3 meets as a whole on a quarterly basis, but also has sponsored a more focused journal club. They have been active in COEP activities and are heavy users of all but the Analytical Instrumentation Service Core. A description of future plans for this Research Core emphasized focused efforts on promoting collaborative research along the three central themes of the core, i.e., genetic susceptibility, genetically defined model systems, and emerging technologies.

描述：该核心由 Cheryl Walker 博士指导，由 15 名 成员中，四名担任核心成员。两个初级 成员是中心的准会员，而一名成员是附属会员。 自上次审查以来，该核心的标题是“ 环境因素对细胞生长和分化的影响”，三位成员 离开该机构，一名将其隶属关系从核心 3 更改为核心 1，一名 会员资格因缺乏参与而被终止，三名 一些人似乎已被招募为新成员。此举的目标 核心是促进 CRED 研究人员之间的互动研究，以定义 细胞和分子对环境暴露的反应并确定 这些反应变异的遗传基础。为了实现这一目标， 提出了四个具体目标： 1) 充当催化剂 CRED 研究人员之间的多学科合作研究 遗传易感性领域、基因定义的动物模型的使用，以及 新兴分子技术； 2）通过以下方式支持核心研究工作 互动讨论论坛、外部研讨会发言人的赞助，以及 试点项目； 3）促进青年教师的进步和鼓励 招募与该中心互动的个人 核心活动； 4) 代表核心 3 的利益 更大的 CRED 中的成员，并作为贡献独特的渠道 中心的核心 3 项专业知识。 分子遗传学和环境致癌核心拥有280万 美元当前赠款支持（NIEHS 支持 34 万美元） 另外 100 万待定。一些现有的和待定的赠款 应用程序涉及新的协作努力。此外，还有一个新计划 项目拨款最近已授予核心 3 研究员之一 这还涉及核心和中心的其他人。研究核心 3 满足 整体为季刊，而且还赞助了更有针对性的期刊 俱乐部。他们一直积极参与 COEP 活动，并且是除 分析仪器服务核心。 对该研究核心未来计划的描述强调了重点 努力促进围绕三个中心主题的合作研究 核心，即遗传易感性、遗传定义的模型系统，以及 新兴技术。