M. D. Anderson Cancer SPORE in Genitourinary Cancers

德克萨斯大学MD安德森癌症中心孢子中心的总体目标是促进在预防、检测和治疗膀胱癌方面的创新转化研究，从而消除这种作为主要健康问题的疾病。我们的癌症中心拥有一群独特的有才华的研究人员，他们致力于临床、翻译和基础膀胱癌研究。我们机构高度重视膀胱癌多学科计划。该计划在该机构内部招聘了教员，加强了研究基础设施，并资助了几项试点研究。我们现在准备利用这个多学科小组开发的框架，使人们在分子和细胞水平上对膀胱癌的了解迅速增加。资助这一孢子将极大地增强我们将膀胱癌生物学的见解转化为更有效地预防、检测和治疗膀胱癌的能力。该孢子包括5个项目，涉及1)膀胱癌的早期发现和化学预防，2)膀胱癌的流行病学，3)膀胱癌进展和治疗中的死亡受体，4)膀胱癌中表皮生长因子受体的生物学和治疗靶点，以及5)改进浅表性膀胱癌的基因治疗。这种孢子解决了临床难题，为化学预防、检测、分子图谱和治疗、生物免疫治疗、化疗、支持性护理和社区意识制定了有效的战略。

The overall goal of this University of Texas MD Anderson Cancer Center SPORE is to facilitate innovative translational research in the prevention, detection, and treatment of bladder cancer leading to the elimination of this disease as a major health problem. Our Cancer Center contains a unique concentration of talented investigators who are dedicated to clinical, translational, and fundamental bladder cancer research. Our institution has given high priority to the Bladder Cancer Multi- disciplinary Program. The Program has recruited faculty within the institution, strengthened the research infrastructure, and funded several pilot studies. We are now poised to take advantage of the framework developed by this multi-disciplinary group to enable a rapid increase in the understanding of bladder cancer at the molecular and cellular level. Funding of this SPORE will greatly enhance our ability to translate insights from bladder cancer biology to more effective prevention, detection, and treatment of bladder cancer. The SPORE includes 5 projects that deal with 1) early detection and chemoprevention of bladder cancer, 2) epidemiology of bladder cancer 3) death receptors in bladder cancer progression and therapy, 4) biology and therapeutic targeting of the epidermal growth factor receptor in bladder cancer, and 5) improving gene therapy for superficial bladder cancer. This SPORE addresses clinical dilemmas develop effective strategies for chemoprevention, detection, molecular profiling and therapeutics, bioimmunotherapy, chemotherapy, supportive care, and community awareness.