SPORE in Genitourinary Cancer

泌尿生殖系统癌症中的孢子

• 批准号: 7679116
• 负责人: COLIN P.N. DINNEY
• 金额: $ 223.33万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7679116
• 关键词: SPORE; Genitourinary; Cancer

DESCRIPTION (provided by applicant): The overall goal of this University of Texas M. D. Anderson Cancer Center Genitourinary SPORE in Bladder Cancer is to facilitate innovative translational research in the prevention, detection, and treatment of this disease leading to the elimination of bladder cancer as a major health problem. We have invested in several major translational research themes: identification of a novel class of genes referred to as "forerunners" whose involvement precedes the loss of function of major tumor suppressor genes in the development of cancer, identification of persons with an increased inherited and/or acquired risk of developing bladder cancer or recurring following therapy by molecular epidemiology, developing targeted bladder cancer therapies for advanced disease, and the development of improved therapy for superficial disease. To achieve these goals, our SPORE has assembled clinicians and basic scientists including urologists, medical oncologists, pathologists, molecular epidemiologists, molecular and cell biologists, biostatisticians, and experts in development of new technologies and informatics. The SPORE includes 4 inter-related projects that deal with 1) early detection of bladder cancer, 2) risk assessment for bladder cancer 3) biology and therapeutic targeting of the epidermal growth factor receptor in bladder cancer, and 4) improving therapy for superficial bladder cancer through adenoviral mediated gene therapy. These projects are supported by 4 Cores: (A) Administrative; (B) Pathology & Tissue Resources; (C). Biostatistics and Bioinformatics; and (D) Clinical Trials and Data Management. All of the scientific projects are translational in nature; focus on human bladder cancer; involve clinical and basic investigators and biostatisticians; interact with the other projects; and utilize Core resources. Innovative Developmental and Career Development Projects have brought new investigators into and stimulated the SPORE that is represented in each of the major projects. This SPORE addresses clinical dilemmas facing patients with all forms of bladder cancer, and will provide a critical component of a larger effort to develop effective strategies for chemoprevention, detection, molecular profiling and therapeutics, bioimmunotherapy, chemotherapy, supportive care, and community awareness. Achievement of the aims and objectives of this proposal will result in a major decrease in the incidence, morbidity and mortality of bladder cancer.

描述(由申请人提供)： 得克萨斯大学安德森癌症中心的总体目标是促进在预防、检测和治疗膀胱癌方面的创新转化研究，从而消除膀胱癌这一主要健康问题。我们在几个主要的翻译研究主题上进行了投资：识别一类被称为“先驱”的新基因，其参与先于主要肿瘤抑制基因在癌症发生中的功能丧失；通过分子流行病学识别具有患膀胱癌或治疗后复发风险增加的遗传和/或获得性风险的人；针对晚期疾病开发有针对性的膀胱癌疗法；以及开发针对浅表疾病的改进疗法。为了实现这些目标，我们的孢子汇集了临床医生和基础科学家，包括泌尿科医生、医学肿瘤学家、病理学家、分子流行病学家、分子和细胞生物学家、生物统计学家以及新技术和信息学开发方面的专家。该孢子包括4个相互关联的项目，涉及1)膀胱癌的早期发现，2)膀胱癌的风险评估，3)膀胱癌中表皮生长因子受体的生物学和治疗靶点，以及4)通过腺病毒介导的基因治疗改进浅表性膀胱癌的治疗。这些项目得到4个核心的支持：(A)行政；(B)病理学和组织资源；(C)。生物统计学和生物信息学；以及(D)临床试验和数据管理。所有科学项目都是翻译性的；重点是人类膀胱癌；临床和基础研究人员和生物统计学家的参与；与其他项目的互动；以及利用核心资源。创新发展和职业发展项目带来了新的调查人员，并刺激了每个重大项目所代表的孢子。这一孢子解决了所有形式的膀胱癌患者面临的临床困境，并将提供更大努力的关键组成部分，以开发有效的战略，用于化学预防、检测、分子图谱和治疗、生物免疫治疗、化疗、支持性护理和社区意识。这项建议的目的和目标的实现将导致膀胱癌的发病率、发病率和死亡率的大幅下降。