M. D. Anderson Cancer SPORE in Genitourinary Cancers

M.D. Anderson 泌尿生殖系统癌症中的癌症孢子

• 批准号: 6656336
• 负责人: COLIN P.N. DINNEY
• 金额: $ 313.23万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656336
• 关键词: bladder neoplasm; cancer prevention; neoplasm /cancer diagnosis; neoplasm /cancer therapy

The overall goal of this University of Texas MD Anderson Cancer Center SPORE is to facilitate innovative translational research in the prevention, detection, and treatment of bladder cancer leading to the elimination of this disease as a major health problem. Our Cancer Center contains a unique concentration of talented investigators who are dedicated to clinical, translational, and fundamental bladder cancer research. Our institution has given high priority to the Bladder Cancer Multi- disciplinary Program. The Program has recruited faculty within the institution, strengthened the research infrastructure, and funded several pilot studies. We are now poised to take advantage of the framework developed by this multi-disciplinary group to enable a rapid increase in the understanding of bladder cancer at the molecular and cellular level. Funding of this SPORE will greatly enhance our ability to translate insights from bladder cancer biology to more effective prevention, detection, and treatment of bladder cancer. The SPORE includes 5 projects that deal with 1) early detection and chemoprevention of bladder cancer, 2) epidemiology of bladder cancer 3) death receptors in bladder cancer progression and therapy, 4) biology and therapeutic targeting of the epidermal growth factor receptor in bladder cancer, and 5) improving gene therapy for superficial bladder cancer. This SPORE addresses clinical dilemmas develop effective strategies for chemoprevention, detection, molecular profiling and therapeutics, bioimmunotherapy, chemotherapy, supportive care, and community awareness.

德克萨斯大学 MD 安德森癌症中心 SPORE 的总体目标是促进膀胱癌预防、检测和治疗方面的创新转化研究，从而消除这种疾病这一主要健康问题。我们的癌症中心拥有一批独特的才华横溢的研究人员，他们致力于临床、转化和基础膀胱癌研究。我们的机构高度重视膀胱癌多学科项目。该计划在该机构内招募了教职人员，加强了研究基础设施，并资助了多项试点研究。我们现在准备利用这个多学科小组开发的框架，在分子和细胞水平上快速增进对膀胱癌的了解。该 SPORE 的资助将大大增强我们将膀胱癌生物学见解转化为更有效地预防、检测和治疗膀胱癌的能力。 SPORE 包括 5 个项目，涉及 1) 膀胱癌的早期检测和化学预防，2) 膀胱癌的流行病学，3) 膀胱癌进展和治疗中的死亡受体，4) 膀胱癌表皮生长因子受体的生物学和治疗靶向，以及 5) 改善浅表性膀胱癌的基因治疗。该 SPORE 解决了临床困境，为化学预防、检测、分子分析和治疗、生物免疫治疗、化疗、支持护理和社区意识制定了有效的策略。