M. D. Anderson Cancer SPORE in Genitourinary Cancers

德克萨斯大学MD安德森癌症中心SPORE的总体目标是促进膀胱癌预防，检测和治疗的创新转化研究，从而消除这种疾病作为一个主要的健康问题。我们的癌症中心拥有独特的人才集中的研究人员，他们致力于临床，转化和基础膀胱癌研究。我们的机构给予高度优先的膀胱癌多学科计划。该方案在机构内招聘了教师，加强了研究基础设施，并资助了几项试点研究。我们现在准备利用这个多学科小组开发的框架，以便在分子和细胞水平上快速增加对膀胱癌的理解。该SPORE的资助将大大提高我们将膀胱癌生物学的见解转化为更有效预防，检测和治疗膀胱癌的能力。SPORE包括5个项目，涉及1）膀胱癌的早期检测和化学预防，2）膀胱癌的流行病学，3）膀胱癌进展和治疗中的死亡受体，4）膀胱癌中表皮生长因子受体的生物学和治疗靶向，以及5）改善浅表性膀胱癌的基因治疗。该SPORE解决了临床困境，为化学预防，检测，分子分析和治疗，生物免疫治疗，化疗，支持性护理和社区意识制定了有效的策略。

The overall goal of this University of Texas MD Anderson Cancer Center SPORE is to facilitate innovative translational research in the prevention, detection, and treatment of bladder cancer leading to the elimination of this disease as a major health problem. Our Cancer Center contains a unique concentration of talented investigators who are dedicated to clinical, translational, and fundamental bladder cancer research. Our institution has given high priority to the Bladder Cancer Multi- disciplinary Program. The Program has recruited faculty within the institution, strengthened the research infrastructure, and funded several pilot studies. We are now poised to take advantage of the framework developed by this multi-disciplinary group to enable a rapid increase in the understanding of bladder cancer at the molecular and cellular level. Funding of this SPORE will greatly enhance our ability to translate insights from bladder cancer biology to more effective prevention, detection, and treatment of bladder cancer. The SPORE includes 5 projects that deal with 1) early detection and chemoprevention of bladder cancer, 2) epidemiology of bladder cancer 3) death receptors in bladder cancer progression and therapy, 4) biology and therapeutic targeting of the epidermal growth factor receptor in bladder cancer, and 5) improving gene therapy for superficial bladder cancer. This SPORE addresses clinical dilemmas develop effective strategies for chemoprevention, detection, molecular profiling and therapeutics, bioimmunotherapy, chemotherapy, supportive care, and community awareness.