Nano-particle motion/transport in biological liquids

生物液体中纳米颗粒的运动/传输

• 批准号: 1946385
• 金额: --
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1946385
• 关键词: Nano; particle; motion; transport; biological

Nanoparticles (NPs) and nanomaterial-based products are attracting an ever-growing interest in the scientific community thanks to their unique properties which allow their usage in different fields to perform a wide range of tasks. Medicine is one of the most promising fields of application for these materials, and an extensive number of researches use NPs for medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy and so on. Nevertheless, there is a lack of knowledge about the dynamics of NPs when dispersed in biological fluids. A clear comprehension of how NPs interact with the surrounding environment is necessary to fully understand their potential toxic health effects. In this study, an investigation on the dynamics of NPs with different size and formulation immersed in a range of biological media will be performed, in order to propose a grouping and categorisation of NPs with similar behaviour and to understand whether and how they interact with the surrounding biological components. Analysis will be conducted using a novel real-time single tracking approach exploiting the caustic phenomena in optical microscopy. Enhanced understanding of NPs behaviour in biological media, will pave the way to a much conscious and safe usage in medicine.

纳米颗粒（NPs）和纳米材料为基础的产品正在吸引越来越多的兴趣在科学界由于其独特的属性，使其在不同领域的使用，以执行广泛的任务。纳米粒子在医学领域有着广泛的应用前景，在医学成像、疾病诊断、药物释放、癌症治疗、基因治疗等方面有着广泛的应用，但目前对纳米粒子在生物体液中的分散动力学研究尚不多见。清楚地了解纳米颗粒如何与周围环境相互作用，对于充分了解其潜在的毒性健康影响是必要的。在这项研究中，将对浸泡在一系列生物介质中的具有不同尺寸和配方的纳米颗粒的动力学进行研究，以提出具有相似行为的纳米颗粒的分组和分类，并了解它们是否以及如何与周围的生物组分相互作用。分析将使用一种新的实时单跟踪方法，利用焦散现象在光学显微镜。加强对纳米粒子在生物介质中行为的理解，将为在医学中更有意识和安全的使用铺平道路。