Elucidating the mechanism of IL-2 cytokine/antibody mediated transplantation tolerance

阐明IL-2细胞因子/抗体介导的移植耐受的机制

• 批准号: nhmrc : 1045647
• 负责人: Dr Kylie Webster
• 金额: $ 41.64万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-mechanism-il-transplantation-tolerance/111775
• 关键词: Elucidating; mechanism; IL; cytokine; antibody

Organ transplantation is a life-saving treatment for end-stage organ failure. However, patients must take immunosuppressive drugs to prevent rejection, a lifetime of which increases the risk of infection and cancer. An alternative to drugs is to manipulate the immune system from within. We discovered a way to boost the immune ‘regulators’ so that they stifle the graft-destroying response. We are optimising this approach with the aim of transplanting organs without long-term immunosuppression.

器官移植是治疗终末期器官衰竭的一种救命方法。然而，患者必须服用免疫抑制药物来防止排斥，因为终生排斥会增加感染和癌症的风险。药物的另一种选择是从内部操纵免疫系统。我们发现了一种增强免疫‘调节器’的方法，这样它们就可以抑制破坏移植物的反应。我们正在优化这种方法，目的是在没有长期免疫抑制的情况下移植器官。