The impact of obesity on immunological tolerance of the fetus

肥胖对胎儿免疫耐受的影响

• 批准号: nhmrc : 1045630
• 负责人: Dr Kylie Webster
• 金额: $ 25.23万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-obesity-immunological-tolerance-fetus/111773
• 关键词: impact; obesity; immunological; tolerance; fetus

Obesity increases the risk of miscarriage during pregnancy. The reasons for this are not known, although it is thought that abnormal levels of hormones and metabolic parameters are a contributing factor. We hypothesise that the immune system plays a role. In this project we will determine if obesity upsets the fine-tuning of the immune system that is crucial for successful pregnancy. Understanding the reason behind adverse pregnancy outcome will allow appropriate management of maternal obesity.

肥胖会增加怀孕期间流产的风险。其原因尚不清楚，尽管人们认为激素和代谢参数的异常水平是一个促成因素。我们假设免疫系统起了一定的作用。在这个项目中，我们将确定肥胖是否会扰乱免疫系统的微调，这对成功怀孕至关重要。了解不良妊娠结局背后的原因将允许适当管理产妇肥胖。