Functional specialization in the inferior colliculus

下丘的功能特化

• 批准号: 6552016
• 负责人: WILLIAM C LOFTUS
• 金额: $ 3.83万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6552016
• 关键词: auditory nuclei; auditory pathways; binaural hearing; cats; electrical measurement; electrodes; electrophysiology; histology; inferior colliculus; innervation; neural information processing; neural transmission; neuronal transport; neurophysiology; olivary body; postdoctoral investigator

DESCRIPTION (provided by applicant): The proposed experiments will test hypotheses regarding the organization and integration of excitatory and inhibitory inputs to the inferior colliculus (IC) from monaural and binaural sources in the lower brain stem. The IC preserves and transforms information from ten numerous sources before projecting it to the auditory thalamus and cortex. Within the IC, the inputs are organized into one map of best frequency, while different zones within a frequency lamina are composed of different combinations of inputs from the various brain stem structures. We will test hypotheses about how specific inputs are segregated and combined, and how this creates functionally specialized zones within the IC. In Aim 1, anterograde tracer techniques will be used to test if inhibitory projections from the dorsal nucleus of the lateral lemniscus (DNLL) converge with excitatory projections from the medial superior olive (MSO). We will also test whether the DNLL inputs to the IC remain segregated from inhibitory inputs from the lateral superior olive (LSO). In Aim 2, retrograde tracer techniques and IC neurophysiology will used to test the hypothesis that some types of functional specialization in the IC is created by segregated inputs from the MSO, LSO, and dorsal cochlear nucleus (DCN). We will also test the hypothesis that inhibitory inputs from DNLL and LSO sharpen distinct types of binaural tuning.

描述（由申请人提供）：拟议的实验将测试有关下脑干中单耳和双耳源的兴奋性和抑制性输入的组织和整合的假设。 IC 保存并转换来自十多个来源的信息，然后将其投射到听觉丘脑和皮层。在 IC 内，输入被组织成一张最佳频率图，而频率层内的不同区域则由来自各种脑干结构的输入的不同组合组成。我们将测试有关如何分离和组合特定输入的假设，以及如何在 IC 内创建功能专用区域的假设。在目标 1 中，将使用顺行示踪技术来测试来自外侧丘系背核 (DNLL) 的抑制性投射是否与来自内侧上橄榄 (MSO) 的兴奋性投射收敛。我们还将测试 IC 的 DNLL 输入是否与来自外侧上橄榄 (LSO) 的抑制输入保持隔离。在目标 2 中，逆行示踪技术和 IC 神经生理学将用于检验以下假设：IC 中某些类型的功能特化是由 MSO、LSO 和耳蜗背核 (DCN) 的隔离输入创建的。我们还将测试以下假设：DNLL 和 LSO 的抑制输入会增强不同类型的双耳调音。