CELLULAR AND MOLECULAR NEUROSCIENCE OF SENSORY SYSTEMS

感觉系统的细胞和分子神经科学

• 批准号: 6515998
• 负责人: THOMAS V GETCHELL
• 金额: $ 15.74万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515998
• 关键词: CELLULAR; MOLECULAR; NEUROSCIENCE; SENSORY; SYSTEMS

DESCRIPTION (from applicant's abstract): The goal of this training program is to prepare promising graduate and medical students, postdoctoral and medical resident fellows for successful careers in Cellular and Molecular Neuroscience of Sensory Systems. This program arises from the perceived benefits of integrated training in the fundamental principles which shape the function of all of our senses and is guided by the following conceptual framework: (I) The sensory systems of the human body are fundamental contributors to the health and well-being of people and are critical substrates for disease processes. (II) These neural systems share many core mechanisms of organization and function, which are especially apparent at the cellular, molecular and genetic levels. (III) Common mechanisms are also reflected in sensory pathologies- specific disease processes often impact multiple sensory systems. (IV) Graduate and postdoctoral research training which integrates cellular, molecular and genetic aspects over a range of sensory systems will enhance the ability of trainees to conduct innovative health-related research. Core mechanisms span multiple sensory systems as do disease processes (e.g. Charcot-Marie-Tooth disease, Norrie disease, Retinitis pigmentosa, Usher's syndrome, Aging and sensory senescence). Thus, there is a need for research training, which integrates across the traditional boundaries of each special-sense tissue. The proposed training faculty consists of 12 members with expertise in the auditory, chemosensory, mechanosensory and visual systems. Faculty research approaches range from mutagenesis and molecular genetics through cell and molecular biology, to intact animal physiology, behavioral analysis and clinical research. The institutional resources, level of extramural support and training histories of the training faculty engender a superb training environment.

描述(摘自申请者摘要)：本培训计划的目标是培养有前途的研究生和医学生、博士后和住院医师，以便在感觉系统的细胞和分子神经科学领域取得成功。这项计划源于对塑造我们所有感官功能的基本原则的综合培训的预期好处，并以以下概念框架为指导：(I)人体的感觉系统是人类健康和福祉的基本贡献者，是疾病过程的关键底物。(2)这些神经系统共有许多核心的组织和功能机制，这在细胞、分子和遗传层面上尤为明显。(3)共同的机制也反映在感官病理学上--特定的疾病过程往往影响多个感官系统。(4)研究生和博士后研究培训将综合各种感官系统的细胞、分子和遗传学方面，将提高受训者进行与健康有关的创新研究的能力。核心机制跨越多个感觉系统，疾病过程也是如此(例如，Charcot-Marie-Tooth病、Norrie病、视网膜色素变性、Usher综合征、衰老和感觉衰老)。因此，有必要进行研究训练，跨越每个特殊感觉组织的传统界限进行整合。拟议的培训教员由12名成员组成，他们在听觉、化学感觉、机械感觉和视觉系统方面具有专业知识。学院的研究方法从突变和分子遗传学到细胞和分子生物学，再到完整的动物生理学、行为分析和临床研究。培训人员的机构资源、外部支持水平和培训历史造就了一流的培训环境。