Elucidating the in vivo role of the pro-survival gene Mcl-1 in mammary gland development and breast cancer

阐明促生存基因 Mcl-1 在乳腺发育和乳腺癌中的体内作用

• 批准号: nhmrc : 1086727
• 负责人: Prof Geoffrey Lindeman
• 金额: $ 44.32万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-vivo-role-breast-cancer/519141
• 关键词: Elucidating; vivo; role; pro; survival

Breast cancer strikes one in 8 women by age 85 and is a major cause of morbidity and mortality. Despite recent improvements, the immense breast cancer burden demands new strategies that will radically improve patient outcomes. This project will address a hallmark of cancer: evasion of apoptosis. Understanding the molecular events that promote tumour survival and resistance to therapy represents a key area in cancer biology that has yet to be properly applied to breast cancer.

85岁以前，每8名女性中就有一人罹患乳腺癌，是发病率和死亡率的主要原因。尽管最近有所改善，但巨大的乳腺癌负担要求采取新的策略，从根本上改善患者的预后。这个项目将解决癌症的一个标志：逃避细胞凋亡。了解促进肿瘤存活和抵抗治疗的分子事件是癌症生物学中的一个关键领域，该领域尚未适当地应用于乳腺癌。