Role of SOCS3 in mammary gland development and tumorigenesis

SOCS3在乳腺发育和肿瘤发生中的作用

• 批准号: nhmrc : 406629
• 负责人: Prof Geoffrey Lindeman
• 金额: $ 14.95万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-socs3-mammary-development-tumorigenesis/77040
• 关键词: Role; SOCS3; mammary; gland; development

We are studying the role of a family of inhibitory molecules (SOCS) in breast tissue; these proteins have been established to have critical roles in the immune system and in regulating growth of the entire animal. We have demonstrated that one member of this family can block the action of the prolactin hormone and have recently obtained evidence that another member of this family, SOCS3, affects survival of breast cells. Furthermore, this protein leads to increased growth when overexpressed in breast cells. We propose to define the normal role of this gene in mouse mammary tissue and to examine the consequences of expressing the gene at high levels in the mammary glands of mice. Inappropriate expression of this gene may predispose humans to breast cancer. SOCS3 expression will be directly studied in a cohort of primary invasive breast cancers with associated clinical outcome data, to determine whether it has a role as a potential prognostic marker.

我们正在研究抑制分子家族（SOCS）在乳腺组织中的作用；这些蛋白质在免疫系统和调节整个动物的生长中起着至关重要的作用。我们已经证明该家族的一个成员可以阻断催乳素激素的作用，最近又获得了该家族的另一个成员SOCS3影响乳腺细胞存活的证据。此外，当这种蛋白质在乳腺细胞中过度表达时，会导致生长加快。我们建议确定该基因在小鼠乳腺组织中的正常作用，并检查在小鼠乳腺中高水平表达该基因的后果。该基因的不适当表达可能使人类易患乳腺癌。SOCS3的表达将直接在一组具有相关临床结果数据的原发性浸润性乳腺癌中进行研究，以确定它是否具有作为潜在预后标志物的作用。