NUTRITIONAL STATUS IN HIV POSITIVE HISPANIC DRUG ABUSERS

HIV 阳性西班牙裔吸毒者的营养状况

• 批准号: 6489488
• 负责人: SHERWOOD GORBACH
• 金额: $ 64.52万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6489488
• 关键词: HIV infections; Hispanic Americans; bioenergetics; blood chemistry; body composition; clinical research; drug abuse; functional ability; gastrointestinal function; human subject; longitudinal human study; malnutrition; nutrient intake activity; nutrition; pathologic process; quality of life; vitamins; weight loss

Progressive weight loss and wasting are common in HIV disease. The causes of wasting in HIV infection included reduced dietary intake, malabsorption and ineffective metabolism of nutrients. It is likely that the causes of wasting differ between drug abusers and non-drug abusers because of differences in diet and metabolism. There is little information on the natural history of HIV infection, including nutritional status and wasting, in HIV-positive drug abusers. This project will study the nutritional status and causes of wasting in HIV-positive drug abusers in the Hispanic community. Emphasis will be placed on the early stages of injection when malnutrition is most amenable to correction.. Recruitment of women will receive high priority. Three groups will be studied: Hispanic HIV-positive drug abusers, Hispanic HIV-negative drug abusers and Hispanic HIV-positive non-drug abusers. The three groups will be followed every 6 months for three years during which they will be examined for changes in nutritional, immunological, and clinical status. Periodic measures of dietary intake, body composition, energy expenditure, serum vitamin levels, immunologic status, gastrointestinal function, functional status, and quality of life will be taken as the clinical course of the disease is tracked. Identify the causes of weight loss and wasting at different periods in the course of HIV disease progression will help in the design of targeted nutrition interventions that are appropriate to the drug abusing, HIV-infected population.

进行性体重减轻和消瘦在艾滋病中很常见。的原因 HIV感染者的消瘦包括饮食摄入减少、吸收不良 和营养物质的无效代谢。很可能是因为 滥用药物者和非滥用药物者之间的浪费不同， 饮食和新陈代谢的差异。有一个小的信息 艾滋病毒感染的自然史，包括营养状况和 艾滋病毒阳性药物滥用者的消瘦。本项目将研究 艾滋病毒阳性药物滥用者的营养状况和消瘦原因 西班牙裔社区。重点将放在早期阶段， 在营养不良最容易纠正的时候注射。招聘 女性将受到高度重视。将研究三组： 西班牙裔艾滋病毒阳性药物滥用者，西班牙裔艾滋病毒阴性药物滥用者， 西班牙裔艾滋病毒阳性非吸毒者。这三个小组将在 每六个月一次，为期三年，在此期间， 营养、免疫和临床状态的变化。定期 饮食摄入量、身体组成、能量消耗、血清 维生素水平，免疫状态，胃肠功能，功能 状态和生活质量将被视为临床过程， 疾病被追踪。找出减肥和浪费的原因， 在艾滋病毒疾病进展过程中的不同时期将有助于 设计适合于儿童的有针对性的营养干预措施， 吸毒、艾滋病毒感染者。