Laser direct-write technique for enabling novel functionalities in paper-based devices

激光直写技术可在纸质设备中实现新颖功能

• 批准号: 1953579
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1953579
• 关键词: Laser; direct; write; technique; enabling

This project focusses on the use of a laser-based direct-write (LDW) technique developed within our group for creation of novel microfluidic devices in porous substrates such as paper. The proprietary technique involves local deposition of a photo-polymer onto a porous substrate at pre-defined locations, and its subsequent polymerisation by exposure from a laser source to form hydrophobic structures that define and demarcate the fluidic flow path and therefore the fluidic device in the porous substrate. The focus of this project is to further explore the usefulness of this LDW technique in improving the performance of laser-patterned microfluidics devices through incorporation of additional functionalities that can allow for the use of such devices in real world point-of-care scenarios. The primary objectives of the project is to develop approaches that use 'smart optically-triggered gates', laser-patterned within a paper-based microfluidic device to implement the following: improvements in sensitivity of the device, quantitative measurements of either a single or multiple biomarkers, detection of multiple biomarkers within a single device and finally, simplification of the sample preparation step - all of which are highly desired for diagnostic applications.

该项目专注于使用我们团队开发的基于激光的直写(LDW)技术，在纸张等多孔衬底上创建新型微流控设备。这项专利技术涉及在预定位置将光聚合物局部沉积到多孔性衬底上，然后通过从激光光源曝光进行聚合，以形成定义和标定流体流动路径的疏水结构，从而定义和标定多孔性衬底中的流体设备。该项目的重点是进一步探索这种LDW技术在通过加入附加功能来改进激光图案化微流控设备的性能方面的有用性，这些功能可以允许在现实世界的护理场景中使用此类设备。该项目的主要目标是开发使用“智能光学触发门”的方法，在纸基微流控设备内进行激光图案化，以实现以下目的：提高设备的灵敏度，对单个或多个生物标志物进行定量测量，在单个设备内检测多个生物标志物，最后，简化样品制备步骤--所有这些都是诊断应用非常需要的。

项目成果

Local photo-polymer deposition-assisted fabrication of multilayer paper-based devices

多层纸基器件的局部光聚合物沉积辅助制造

• DOI: 10.1016/j.snb.2020.128574
• 发表时间: 2020
• 期刊: Chemical
• 作者: Galanis P

Laser-direct-writing to enable filtration in paper-based devices

激光直写可在纸质设备中实现过滤

• DOI: 10.1117/12.2508753
• 发表时间: 2019
• 作者: Galanis P

Performance improvement and add-on functionalities to conventional lateral-flow devices using a laser direct-write patterning technique

使用激光直写图案化技术对传统横流设备进行性能改进和附加功能

• DOI: 10.1364/cleopr.2018.w1e.4
• 发表时间: 2018
• 作者: Sones C