Development of defect models for the ankle to evaluate changes in joint geometry and tribology as a predictor for degeneration

这个项目的目的是开发临床相关的实验和/或计算模型来表示脚踝的骨缺陷，以探索对力学和摩擦学的影响，以确定潜在的退变途径。目的：1)识别与骨缺损相关的踝关节的几何变化识别典型的“正常”距骨几何形状识别几何变化相关的几何变化：血友病相关的缺陷(典型的关节表面几何形状)骨软骨缺陷(位置和大小/形状)2)以确定骨的力学性质的变化。组织的力学特征(如果有)基于医学成像的计算模型3)典型缺陷模型的发展(使用来自1和2的数据)身体骨组织的生物化学退行性变的方法研究具有代表性缺陷和骨结构的距骨模型的3D打印踝关节的计算有限元模型4)在适当的条件下(实验和/或计算)研究缺陷对踝关节摩擦学的影响在一系列合适的条件下(实验和/或计算)静态载荷(接触压力，例如Tekcan)在自然关节模拟器中进行实验测试(疲劳、摩擦、磨损)用于研究参数范围的有限元模型天然踝关节几何形状的特征以踝关节为重点的新型实验和/或计算方法的发展到目前为止，有限的自然踝关节模型已经通过实验或计算进行，因此该项目在开发用于预测退变的模型的能力方面代表了生物工程的重大进步。为未来的治疗开发提供了潜在的平台

The aim of this project is to develop clinically relevant experimental and/or computational models to represent bony defects of the ankle, in order to explore the influence on mechanics and tribology to identify a potential degeneration pathway.Objectives:1)To identify the geometric changes in the ankle relating to bony defectsidentify typical 'normal' talar geometryIdentify changes in geometry relating:Haemophilia related defects (typically joint surface geometry)Osteochondral defect (location and size/shape)2)To identify changes in mechanical properties of the bone. Mechanical characterisation of tissues (where available)Computational modelling based on medical imaging3)Development of representative defect models (using data from 1 & 2)Investigation of methods for developing 'degraded bone'Biochemical degeneration of cadaveric bone tissue3D printing of talar models with representative defects and bony structureComputational FE models of the ankle joint4)To investigate the effect of defects on the tribology of the ankle joint under a range of appropriate conditions(experimentally and/or computationally)static loading (contact pressure e.g. Tekscan)experimental testing in a natural joint simulator (fatigue, friction, wear) Finite element models to investigate range of parametersCharacterisation of the geometry of the natural ankleDevelopment of novel experimental and/or computational methods focussed on the ankle jointLimited natural ankle modelling either experimentally or computationally has been undertaken to date, and therefore this project represents a significant bioengineering advance in the ability to develop a model for predicting degeneration.Potential platform for future treatment development