Aluminum bioavailability from foods

食物中铝的生物利用度

• 批准号: 6417774
• 负责人: Robert Allen Yokel
• 金额: $ 23.63万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-08 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6417774
• 关键词: Alzheimer's disease; aluminum; angiosperms; atomic absorption spectrometry; bioaccumulation; brain; dairy products; food; food contamination; gastrointestinal absorption /transport; laboratory rat; male; mass spectrometry; neural degeneration; radionuclides; tea; vegetables; water quality; water supply

There is concern about brain aluminum accumulation over the life span that might contribute to Alzheimer's disease and related neurodegenerative disorders. The overall objective of the proposed research is to test the null hypothesis that the bioavailability of Al is comparable from foods and from drinking water. If the null hypothesis is accepted the concern about Al intake for typical Americans should focus on food and not drinking water. The specific aims are to produce food products containing 26Al in the normal chemical species for these foods and determine Al oral bioavailability from these selected representative foods, compared to Al oral bioavailability from drinking water. Foods to be produced are a baked good and a processed cheese, in which 26Al will be incorporated during food production, and spinach and tea, in which 26Al will be incorporated during their hydroponic production. Al bioavailability will be determined from the area under the serum 26Al concentration x time curve after bolus administration of the 26Al-containing food compared to the equivalent term obtained from serum 27Al concentration produced by continuous intravenous 27Al infusion throughout the study. 26Al will be analyzed by accelerator mass spectroscopy; 27Al by atomic absorption spectroscopy. It is hypothesized that oral Al bioavailability from food will be less than from water, due to Al binding to food components that inhibit its absorption. The results will resolve the controversy whether drinking water contributes a significant amount of the Al that is absorbed by the human. The results will suggest whether health-based standards to regulate Al in drinking water should be considered by regulatory agencies or whether reduction of absorbed Al in the human can be more effectively achieved by reducing Al in foods.

人们担心在生命周期中大脑铝的积累可能会导致阿尔茨海默病和相关的神经退行性疾病。 拟议研究的总体目标是检验零假设，即食品和饮用水中Al的生物利用度相当。 如果零假设被接受，典型美国人对铝摄入量的关注应该集中在食物而不是饮用水上。 具体的目的是生产食品中含有26铝在正常的化学物种，这些食品和确定铝口服生物利用度从这些选定的代表性食品相比，铝口服生物利用度从饮用水。 待生产的食品是烘焙食品和加工奶酪，其中26 Al将在食品生产期间掺入，以及菠菜和茶，其中26 Al将在它们的水培生产期间掺入。 将通过含26 Al食物推注给药后血清26 Al浓度x时间曲线下面积与整个研究期间通过连续静脉输注27 Al产生的血清27 Al浓度获得的等效项进行比较，确定Al生物利用度。 26 Al将通过加速器质谱分析; 27 Al通过原子吸收光谱分析。 据推测，口服铝从食物中的生物利用度将低于水，由于铝结合到食物成分，抑制其吸收。 这些结果将解决饮用水是否对人体吸收的铝有显著贡献的争议。 研究结果将表明，是否基于健康的标准，以调节饮用水中的铝应考虑由监管机构或是否减少吸收的铝在人体内可以更有效地实现减少食品中的铝。