Aluminum bioavailability from foods

食物中铝的生物利用度

• 批准号: 6620458
• 负责人: Robert Allen Yokel
• 金额: $ 21.95万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-08 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620458
• 关键词: Alzheimer's disease; aluminum; angiosperms; atomic absorption spectrometry; bioaccumulation; brain; dairy products; food; food contamination; gastrointestinal absorption /transport; laboratory rat; male; mass spectrometry; neural degeneration; radionuclides; tea; vegetables; water quality; water supply

There is concern about brain aluminum accumulation over the life span that might contribute to Alzheimer's disease and related neurodegenerative disorders. The overall objective of the proposed research is to test the null hypothesis that the bioavailability of Al is comparable from foods and from drinking water. If the null hypothesis is accepted the concern about Al intake for typical Americans should focus on food and not drinking water. The specific aims are to produce food products containing 26Al in the normal chemical species for these foods and determine Al oral bioavailability from these selected representative foods, compared to Al oral bioavailability from drinking water. Foods to be produced are a baked good and a processed cheese, in which 26Al will be incorporated during food production, and spinach and tea, in which 26Al will be incorporated during their hydroponic production. Al bioavailability will be determined from the area under the serum 26Al concentration x time curve after bolus administration of the 26Al-containing food compared to the equivalent term obtained from serum 27Al concentration produced by continuous intravenous 27Al infusion throughout the study. 26Al will be analyzed by accelerator mass spectroscopy; 27Al by atomic absorption spectroscopy. It is hypothesized that oral Al bioavailability from food will be less than from water, due to Al binding to food components that inhibit its absorption. The results will resolve the controversy whether drinking water contributes a significant amount of the Al that is absorbed by the human. The results will suggest whether health-based standards to regulate Al in drinking water should be considered by regulatory agencies or whether reduction of absorbed Al in the human can be more effectively achieved by reducing Al in foods.

人们担心，在人的一生中，大脑中铝的积累可能会导致阿尔茨海默病和相关的神经退行性疾病。拟议研究的总体目标是检验零假设，即食品和饮用水中Al的生物利用度是相当的。如果零假设被接受，对典型美国人的人工智能摄入量的关注应该集中在食物上，而不是饮用水上。具体目标是为这些食品生产含有正常化学成分的26Al的食品，并确定这些选定的代表性食品中的Al的口服生物利用度，与饮用水中的Al的口服生物利用度进行比较。要生产的食品是烘焙食品和加工奶酪，其中26Al将在食品生产过程中加入，以及菠菜和茶，其中26Al将在水培生产过程中加入。Al的生物利用度将通过在整个研究过程中连续静脉输注27Al所产生的血清27Al浓度x时间曲线下的面积来确定。铝将通过加速器质谱分析；27Al原子吸收光谱法。据推测，由于Al与食物成分结合抑制其吸收，从食物中口服Al的生物利用度将低于从水中。这一结果将解决人体吸收的人工智能中是否有大量来自饮用水的争议。研究结果将表明，监管机构是否应该考虑制定以健康为基础的标准来规范饮用水中的铝，或者是否可以通过减少食物中的铝来更有效地减少人体吸收的铝。