Endocrine regulation of penile development

阴茎发育的内分泌调节

• 批准号: nhmrc : 566958
• 负责人: A/Pr Andrew Pask
• 金额: $ 31.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endocrine-regulation-penile-development/101345
• 关键词: Endocrine; regulation; penile; development

Hypospadias is one of the most common developmental defects in humans, yet over two thirds of the cases cannot be explained. Our recent studies using marsupials show that this process is mediated by 5-alpha-androstanediol, a hormone with previously undetermined physiological function. This study will provide novel data on the interactions of the genes and hormones that will inform our understanding of this common developmental defect of male development

尿道下裂是人类最常见的发育缺陷之一，但超过三分之二的病例无法解释。我们最近对有袋动物的研究表明，这一过程是由5- α -雄甾二醇介导的，这是一种先前未确定生理功能的激素。这项研究将提供基因和激素相互作用的新数据，这将使我们了解男性发育中这种常见的发育缺陷