Hypospadias and control of urethral closure

尿道下裂和尿道闭合的控制

• 批准号: nhmrc : 1063356
• 负责人: A/Pr Andrew Pask
• 金额: $ 48.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hypospadias-control-urethral-closure/455051
• 关键词: Hypospadias; control; urethral; closure

Hypospadias, is a common defect, in which the urethra opens abnormally along the shaft of the penis not at the tip. It affects 1 in every 125 boys born in Victoria each year. However, the cause(s) of over two-thirds of these cases cannot be explained. Our studies using marsupials show that this process is mediated by a hormone (5alpha-androstanediol), with previously undetermined physiological function. This study will provide novel data on the interactions of the genes and hormones that result in defects of penile development.

尿道下裂，是一种常见的缺陷，其中尿道不正常地沿着阴茎的轴而不是在尖端打开。每年在维多利亚出生的每125个男孩中就有一个受到影响。然而，超过三分之二的案件的原因无法解释。我们对有袋类动物的研究表明，这一过程是由一种激素（5 α-雄甾烷）介导的，其生理功能以前尚未确定。本研究将为基因和激素的相互作用导致阴茎发育缺陷提供新的数据。