Hormonal responsive coding and non-coding genes in penile differentiation and hypospadias
Hormonal responsive coding and non-coding genes in penile differentiation and hypospadias
批准号:
nhmrc : 1138950
负责人:
A/Pr Andrew Pask
金额:
$56.47万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
尿道下裂是一种阴茎不能正确形成的畸形,是第二大常见的出生缺陷,约1%的男孩会发生这种情况。它对新生儿和父母都造成了痛苦,需要手术干预,是一种成本负担,对孩子来说是一种风险。此外,它还经常与其他异常有关。我们有一个新的模型,在这个模型中,我们可以诱导阴茎异常,并确定激素暴露和有缺陷的阴茎分化之间的联系。
英文摘要
Hypospadias, a failure of the correct formation of the penis, is the second-most common birth defect, occurring in around 1% of boys. It causes distress to both newborn and parents, requiring surgical intervention, and is a burden of cost and is a risk to the child. Furthermore, it is frequently associated with other abnormalities. We have a novel model in which we can induce penis abnormalities and define the link between hormonal exposures and defective penis differentiation.
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会议论文
Endocrine control of cell fate in the gonad
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批准号:nhmrc : 1142481
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项目类别:Project Grants
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依托单位:
Endocrine control of cell fate in the gonad
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Hormonal responsive coding and non-coding genes in penile differentiation and hypospadias
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Endogenous oestrogen is a key missing link in urethral hypospadias
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Endogenous oestrogen is a key missing link in urethral hypospadias
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