Functional highly ordered mesoporous phosphate glasses prepared by sol-gel

目标：-通过溶胶-凝胶法生产用于生物医学应用的多孔磷酸盐玻璃材料。这种孔洞将允许药物的装载和释放。-探索其他软化学方法来生产磷酸盐玻璃。-通过在玻璃中加入不同的金属离子，如银、铜和锌来探索不同的玻璃成分。许多金属离子已被证明在伤口愈合和成骨机制中起着重要作用，其他离子如银被认为具有抗菌性能。-研究所产生的玻璃的物理和化学性质，如生物兼容性、抗菌性能、溶解、强度和化学稳定性。方法：-使用表面活性物质作为模板，在纳米尺度上制备具有气孔的玻璃。表面活性剂在生产后将被去除，留下毛孔。-将使用静电纺丝生产多孔支架。这将允许更大的表面积和更高的载药量。

Aims:- To produce porous phosphate glass materials via the sol-gel route for the use in biomedical applications. The porosity will allow for drug loading and release.- To explore other soft-chemistry routes to produce phosphate glasses.- To explore different glass compositions by incorporating various metal ions into the glasses such as silver, copper and zinc. Many metal ions have been shown to play important roles in the wound healing and bone-production mechanisms and other ions such as silver have been presented as possessing antibacterial properties.- To study the physical and chemical properties of glasses produced such as biocompatibility, antibacterial properties, dissolution, strength and chemical stability.Methodology:- Produce glasses with pores on the nanoscale with the use of surfactants as templating agents. The surfactants will be removed after production leaving pores.- Porous scaffolds will be produced with the use of electrospinning. This will allow for a larger surface area and higher drug-loading capacities.