Endothelial dysfunction as a therapeutic target in severe malaria

内皮功能障碍作为严重疟疾的治疗靶点

• 批准号: nhmrc : 605807
• 负责人: A/Pr Tsin Yeo
• 金额: $ 56.17万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endothelial-dysfunction-therapeutic-severe-malaria/77410
• 关键词: Endothelial; dysfunction; therapeutic; target; severe

Even with very best drugs to kill malaria parasites, over 15% of patients with severe malaria still die. Their blood vessels are clogged up by malaria parasites. We have shown that the cells lining their blood vessels can't make enough nitric oxide to keep them non-sticky and allow blood through. We want to test whether giving arginine can 1) increase nitric oxide, 2) open up the clogged blood vessels and 3) dampen down other processes that clog up blood vessels in severe malaria.

即使使用最好的药物杀死疟原虫，仍有超过15%的严重疟疾患者死亡。他们的血管被疟疾寄生虫堵塞了。我们已经证明，血管内壁的细胞不能产生足够的一氧化氮来保持它们不粘并允许血液通过。我们想测试给予精氨酸是否可以1）增加一氧化氮，2）打开堵塞的血管，3）抑制严重疟疾中堵塞血管的其他过程。