Targeting microvascular dysfunction in severe malaria

针对严重疟疾的微血管功能障碍

• 批准号: nhmrc : GNT1098334
• 负责人: A/Pr Tsin Yeo
• 金额: $ 87.19万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-microvascular-dysfunction-severe-malaria/1345984
• 关键词: Targeting; microvascular; dysfunction; severe; malaria

In severe malaria blood vessels cannot make enough protective nitric oxide (NO). The gel-like lining of blood vessels (glycocalyx) is needed to produce NO, but this is damaged in some severe infections. We will test whether glycocalyx is lost in malaria and how it affects blood vessel NO and function in human volunteer infections and in patients with and without severe malaria. We will test whether a salt nitrite, can be used to safely increase NO and blood vessel function in severe malaria.

在严重的疟疾中，血管不能产生足够的保护性一氧化氮（NO）。血管的凝胶样衬里（糖萼）需要产生NO，但在一些严重感染中会受损。我们将测试糖萼是否在疟疾中丢失，以及它如何影响人类志愿者感染以及患有和不患有严重疟疾的患者的血管NO和功能。我们将测试亚硝酸盐是否可以安全地用于增加严重疟疾患者的NO和血管功能。