Targeting microvascular dysfunction in severe malaria

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In severe malaria blood vessels cannot make enough protective nitric oxide (NO). The gel-like lining of blood vessels (glycocalyx) is needed to produce NO, but this is damaged in some severe infections. We will test whether glycocalyx is lost in malaria and how it affects blood vessel NO and function in human volunteer infections and in patients with and without severe malaria. We will test whether a salt nitrite, can be used to safely increase NO and blood vessel function in severe malaria.