Bionic Baroreflex System for Blood Pressure Control
Bionic Baroreflex System for Blood Pressure Control
批准号:
6444469
负责人:
Andre Diedrich
金额:
$14.71万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-15 至 2004-07-31
中文摘要
描述(由申请人提供):多系统萎缩患者
英文摘要
DESCRIPTION (provided by applicant): Patients with multiple system atrophy
(MSA), a sporadic and progressive neurodegenerative disorder, suffer from
orthostatic hypotension, postprandial hypotension and supine hypertension.
Hypotension causes presyncopal symptoms usually within seconds of standing and
requires the patient to sit or lie down to prevent syncope. Supine hypertension
reduces sleep quality through excessive nocturnal diuresis, and results in
blood volume loss during the night, which aggravates orthostatic hypotension
during the day. New strategies of treatments are required which take into
account this cycling between hypertension and hypotension.
Recent studies in our laboratory have yielded the unexpected observation that
sympathetic activity is present in MSA, but is not subject to normal control
mechanisms. This sympathetic activity produces inappropriate supine
hypertension, but is not able to prevent the profound orthostatic hypotension.
The identification of residual sympathetic activity in MSA has important
implications for new therapeutic approaches. We hypothesize that a bionic
baroreflex system based on electrical epidural spinal stimulation will help to
replace the missing control of sympathetic activity by the vasomotor center.
Preliminary data in animals showed that such a system maintained blood pressure
during orthostatic stress. The purpose of this grant proposal is to search for
an effective and practical bionic baroreflex system for patients with MSA and
baroreflex failure. First, we will develop a prototype bionic baroreflex
control system using baroreflex-denervated rats. Then, the system will be
applied to control artificially, the muscle sympathetic nerve activity in
patients who already have an epidural electrical stimulator in place for the
control of chronic pain. A Phase II study would involve studies in animals and
in patients with MSA to determine the long-term efficacy of the bionic
baroreflex system in improving blood pressure control.
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会议论文
Autonomic Determinants of Postural Tachycardia Syndrome
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批准号:10473598
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项目类别:
-
资助金额:$42.33万
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财政年份:2019
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负责人:Andre Diedrich
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依托单位:
Autonomic Determinants of Postural Tachycardia Syndrome
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批准号:9898448
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项目类别:
-
资助金额:$42.33万
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财政年份:2019
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负责人:Andre Diedrich
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依托单位:
Autonomic Determinants of Postural Tachycardia Syndrome
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批准号:10237867
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项目类别:
-
资助金额:$42.33万
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财政年份:2019
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负责人:Andre Diedrich
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依托单位:
ANALYTICAL & PHENOTYPING CORE
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批准号:8147957
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项目类别:
-
资助金额:$15.01万
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财政年份:2010
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负责人:Andre Diedrich
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依托单位:
Analytical and Phenotyping Core
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批准号:7252850
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项目类别:
-
资助金额:$14.75万
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财政年份:2007
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负责人:Andre Diedrich
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依托单位:
ANALYTICAL & PHENOTYPING CORE
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批准号:8266426
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项目类别:
-
资助金额:$15.01万
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财政年份:--
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负责人:Andre Diedrich
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依托单位:
Analytical & Phenotyping Core
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批准号:9063593
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项目类别:
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资助金额:$23.68万
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财政年份:--
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负责人:Andre Diedrich
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依托单位:
Analytical & Phenotyping Core
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批准号:8293475
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项目类别:
-
资助金额:$24.61万
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财政年份:--
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负责人:Andre Diedrich
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依托单位:
Analytical & Phenotyping Core
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批准号:8458080
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项目类别:
-
资助金额:$21.79万
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财政年份:--
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负责人:Andre Diedrich
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依托单位:
Analytical & Phenotyping Core
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批准号:8661207
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项目类别:
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资助金额:$24.87万
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财政年份:--
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负责人:Andre Diedrich
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依托单位:
海外基金