K24 MID-CAREER CLINICAL INVESTIGATOR AWARD

K24 职业生涯中期临床研究者奖

• 批准号: 6510051
• 负责人: John A Bartlett
• 金额: $ 8.78万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6510051
• 关键词: AIDS; AIDS therapy; HIV infections; antiAIDS agent; clinical research; human subject; human therapy evaluation

DESCRIPTION (adapted from application's abstract): John A. Bartlett seeks the K24 Mid-Career Investigator Award to enhance his opportunity to perform patient-oriented research, and mentor new investigators entering a career of clinical investigation. If Dr. Bartlett receives this award he will decrease his patient care responsibilities to 1/2 day per week, and he will receive biostatistical collaboration from Dr. Lloyd Edwards. Dr. Bartlett's research focuses on HIV pathogenesis and antiretroviral therapies, especially translational, investigator-initiated projects. His immediate research objectives include the investigation of antiretroviral treatment failure, and efforts to diminish the reservoir of chronically HIV-infected cells in persons receiving antiretroviral therapy. His long-term career objective centers on the continued incorporation of scientific observations on HIV pathogenesis into improved antiretroviral treatment strategies. Dr. Bartlett collaborates extensively with other basic and clinical sciences investigators at Duke University through ACTG, CFAR, SPIRAT and GCRC Awards, and his research efforts will be guided by a Scientific Advisory Committee. Dr. Bartlett has immediate access to 1058 HIV-infected adults and 109 HIV infected children followed at Duke University. He has successfully mentored numerous clinical investigators, including investigators involved with current projects. These mentorship activities are strongly supported by leadership of the Department of Medicine and the Division of Infectious Diseases, and an AIDS Training Grant, which provides financial support for young investigators.

描述（改编自申请摘要）：John A.巴特利特寻求 K24职业中期调查员奖，以提高他的表现机会 以病人为导向的研究，并指导新的研究人员进入职业生涯， 临床研究如果巴特利特博士获得这个奖项，他将减少 他的病人护理责任，每周1/2天，他将收到 生物统计学合作，劳埃德·爱德华兹博士。巴特利特博士的研究 侧重于艾滋病毒发病机制和抗逆转录病毒疗法，特别是 翻译，翻译发起的项目。他的直接研究 目标包括调查抗逆转录病毒治疗失败的情况， 努力减少人体内慢性艾滋病毒感染细胞的储存库 接受抗逆转录病毒治疗他的长期职业目标集中在 继续纳入关于艾滋病毒发病机理的科学观察， 改进抗逆转录病毒治疗策略。巴特利特博士与 与杜克大学的其他基础和临床科学研究人员进行了广泛的合作 大学通过ACTG，CFAR，SPIRAT和GCRC奖，以及他的研究 这些工作将由一个科学咨询委员会指导。巴特利特医生 立即接触1 058名艾滋病毒感染成人和109名艾滋病毒感染儿童 在杜克大学学习。他成功地指导了许多临床 调查人员，包括参与当前项目的调查人员。这些 师友活动得到部门领导的大力支持 医学部和传染病部，以及艾滋病培训 格兰特基金会为年轻的研究人员提供经济支持。