Enhanced Vascularisation and Growth of Stem Cell Derived Human Myocardial Grafts

干细胞来源的人心肌移植物的血管化和生长增强

• 批准号: nhmrc : 1012934
• 负责人: Dr James Chong
• 金额: $ 25.49万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhanced-vascularisation-growth-myocardial-grafts/109690
• 关键词: Enhanced; Vascularisation; Growth; Stem; Cell

300 000 Australians currently have heart failure with 400 new cases weekly. New therapies are urgently needed. We can now create heart muscle grafts that can be transplanted after ñheart attackî but graft survival in this hostile environment is low. This project will investigate use of different combinations of human cell types that will cooperate together to improve survival/function of heart muscle grafts, advancing this promising strategy towards being a viable new treatment for heart failure

目前有30万澳大利亚人患有心力衰竭，每周新增400例。迫切需要新的治疗方法。我们现在可以创造出可以在心脏病发作后移植的心肌移植物，但移植物在这种恶劣环境中的存活率很低。这个项目将研究人类细胞类型的不同组合的使用，它们将共同合作来改善心肌移植物的存活/功能，推动这一有希望的策略成为一种可行的治疗心力衰竭的新方法。