Optimising human vascularisation and liver tissue engineering models to develop functional bio-artificial human liver tissue

优化人体血管和肝脏组织工程模型，开发功能性生物人工肝脏组织

• 批准号: nhmrc : GNT1092922
• 负责人: Dr Kiryu Yap
• 金额: $ 12.07万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-human-vascularisation-liver-tissue/1345898
• 关键词: Optimising; human; vascularisation; liver; tissue

This project aims to grow human blood vessels and liver cells derived from human stem cells within a supporting scaffold to generate a “liver in a dish”. Transplantation involves connecting blood vessels in this structure to those of the recipient. This should restore function in mice with human-like liver disease, thereby demonstrating potential of this technology to be developed as an alternative to liver transplantation.

该项目的目标是在支撑支架内培养来自人类干细胞的人体血管和肝细胞，以产生一个“盘子里的肝脏”。移植包括将这种结构中的血管与受者的血管连接起来。这应该会恢复患有类似人类肝病的小鼠的功能，从而展示了这项技术作为肝移植替代方案开发的潜力。