Low Level Traces Mapping using Monochromatic X-Rays

使用单色 X 射线进行低级迹线映射

• 批准号: 6443084
• 负责人: ZEWU CHEN
• 金额: $ 30.39万
• 依托单位: X-RAY OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443084
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; brain mapping; cadmium; chromium; clinical research; imaging /visualization /scanning; iron; manganese; measurement; metals; monitoring device; neurochemistry; optics; radiofluorescent probe; selenium; trace elements

DESCRIPTION (provided by applicant): There are important medical applications that will benefit from a desktop imaging tool which detects and maps parts per billion level metals and other heavy elements in tissues in vitro and in vivo. A compact instrument will be proposed for elemental imaging of dry tissues as well as living tissues based on monochromatic micro x-ray fluorescence (MMXRF). This tool, based on innovative, large-aperture, doubly-curved crystal optics, is capable of detecting ppb levels of transition metal and heavy elements with a spatial resolution of a few micrometers. This would assist in the research of Alzheimer?s and Parkinson?s diseases, prostate cancer and other medical issues. This can also be a relatively inexpensive tool for the screening and monitoring of environmental and occupational exposure of toxic elements. The Phase I research has been very successfully completed and the feasibility of the MMXRF has been clearly demonstrated. In this Phase II project, a prototype desktop MMXRF system will be developed that incorporates an interchangeable modular x-ray beam unit to probe samples with different x-ray energies. Spatial distribution of Mn, Fe, Se, and Cd will be mapped in tissues related to Alzheimer?s disease and prostate cancer using the prototype system. PROPOSED COMMERCIAL APPLICATIONS: Commercial applications will be seen in analytical labs and medical research centers in their investigation of the effects of toxic metals and other trace elements on biological functions. Simplified and inexpensive systems could have have applications for clinical screening of toxic element exposures and environmental monitoring. Other non-medical applications include materials science, forensics, the semiconductor industry and other industries where the sub ppm elemental imaging is desired.

描述（由申请人提供）：有重要的医疗应用 这将受益于桌面映像工具， 10亿级金属和其他重元素在体内外组织中的作用。 将提出一种紧凑的仪器用于干燥组织的元素成像， 以及基于单色显微X射线荧光（MMXRF）的活组织。 这款工具基于创新的大孔径双曲面晶体光学器件， 能够检测ppb级的过渡金属和重元素， 几微米的空间分辨率。这将有助于研究 老年痴呆症？s和帕金森？前列腺癌和其他疾病。 这也可以是一种相对便宜的筛选和监测工具 环境和职业暴露的有毒元素。I期 研究已经非常成功地完成，MMXRF的可行性 已经被清楚地证明了。在这个第二阶段的项目中， MMXRF系统将被开发为包含可互换的模块化 X射线束单元，以不同的X射线能量探测样品。空间 Mn、Fe、Se和Cd的分布将在与 老年痴呆症？的疾病和前列腺癌使用原型系统。 拟议的商业应用： 商业应用将在分析实验室和医学研究中心的有毒金属和其他微量元素对生物功能的影响的调查中看到。简化和廉价的系统可以应用于有毒元素暴露的临床筛查和环境监测。其他非医疗应用包括材料科学、法医学、半导体工业和其他需要亚ppm元素成像的行业。