ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
环境对大脑可塑性的影响
基本信息
- 批准号:6530876
- 负责人:
- 金额:$ 18.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-03-10 至 2003-08-31
- 项目状态:已结题
- 来源:
- 关键词:behavior test behavioral /social science research tag behavioral genetics densitometry environment ethology hormone regulation /control mechanism in situ hybridization lizards mature animal neural plasticity neuroanatomy neuroendocrine system neuroregulation organ culture polymerase chain reaction radioimmunoassay sex behavior sex determination sex differentiation social behavior statistics /biometry steroid hormone steroid hormone receptor temperature vertebrate embryology
项目摘要
DESCRIPTION (Adapted from applicant's abstract): This research addresses
the fundamental question of what determines behavioral variation. Many
environmental variables can produce predictable effects on phenotype. One
such variable is the incubation temperature of eggs in many reptiles. In
the leopard gecko, embryos become male or female depending upon their
temperature during development. In addition, between-sex as well as
within-sex differences attributable to incubation temperature have been
found in morphology, secretion of and sensitivity to steroid hormones,
sociosexual behavior, reproductive success, and in the neuroanatomy and
metabolic activity of brain areas that mediate sociosexual behaviors. These
environmental effects are analogous to the effect of intrauterine
environment in mammals, including humans. Given the homology of the
endocrine and nervous systems across vertebrates, it is important to
determine if homologous mechanisms underlie these analogous effects on
behavior. If the mechanism underlying environmental effects on behavior in
the leopard gecko is conserved (i.e., via sex steroids), this research will
lend new insight into the evolution of sexual differentiation because
temperature-dependent sex determination is thought to be the evolutionary
precursor to genotypic sex determination (present in birds and mammals) and
because reptiles are the ancestors of both birds and mammals. If the
mechanism is different (i.e., direct temperature effects), this research
would elucidate a novel process of sexual differentiation that may also be
present in birds and mammals but, because of homeothermy, is masked. This
latter possibility is especially important because young birds and mammals
cannot regulate their body temperature as do adults. The proposed research
is broadly categorized into three groups: thermoregulation and its relation
to sociosexual behaviors (i.e., the degree to which the neural substrates
mediating thermoregulatory and sociosexual behavior overlap), the
development of the neural phenotypes of these brain regions and hormone
milieus, and the effects of hormonal manipulations during development and
neural manipulations in adulthood on thermoregulatory and sociosexual
behaviors. The final category of experiments is particularly important as
it will discern whether the incubation temperature effects are direct or
indirect.
描述(改编自申请人的摘要):这项研究涉及
决定行为变异的基本问题。 许多
环境变量可以对表型产生可预测的影响。 一
这种变量是许多爬行动物的卵的孵化温度。 在
豹纹守宫,胚胎变成雄性或雌性取决于它们的
开发过程中的温度。 此外,两性之间以及
孵化温度造成的性别差异
在类固醇激素的形态、分泌和敏感性中发现,
社会性行为、生殖成功以及神经解剖学和
介导社会性行为的大脑区域的代谢活动。 这些
环境影响类似于宫内胎儿的影响
包括人类在内的哺乳动物的环境。 鉴于同源性
脊椎动物的内分泌和神经系统,重要的是
确定这些类似效应是否存在同源机制
行为。 如果环境影响行为的潜在机制
豹纹壁虎是保守的(即通过性类固醇),这项研究将
为性别分化的进化提供新的见解,因为
温度依赖性性别决定被认为是进化过程
基因型性别决定的前体(存在于鸟类和哺乳动物中)和
因为爬行动物是鸟类和哺乳动物的祖先。 如果
机制不同(即直接温度效应),本研究
将阐明一种新的性别分化过程,也可能是
存在于鸟类和哺乳动物中,但由于恒温,被掩盖。 这
后一种可能性尤其重要,因为幼鸟和哺乳动物
无法像成年人一样调节体温。 拟议的研究
大致分为三组:体温调节及其关系
社会性行为(即神经基质的程度)
介导体温调节和社会性行为重叠),
这些大脑区域的神经表型和激素的发展
环境以及发育和发育过程中荷尔蒙操纵的影响
成年期对体温调节和社会性行为的神经操作
行为。 最后一类实验尤其重要,因为
它将辨别孵化温度影响是直接影响还是
间接。
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Epigenetic modifications of brain and behavior: theory and practice.
大脑和行为的表观遗传修饰:理论与实践。
- DOI:10.1016/j.yhbeh.2010.07.001
- 发表时间:2011-03
- 期刊:
- 影响因子:3.5
- 作者:Crews, David
- 通讯作者:Crews, David
Functional connectivity among limbic brain areas: differential effects of incubation temperature and gonadal sex in the leopard gecko, Eublepharis macularius.
边缘脑区域之间的功能连接:孵化温度和性腺性别对豹纹壁虎 Eublepharis macularius 的不同影响。
- DOI:10.1159/000006648
- 发表时间:2000
- 期刊:
- 影响因子:0
- 作者:Sakata,JT;Coomber,P;Gonzalez-Lima,F;Crews,D
- 通讯作者:Crews,D
Constraints on temperature-dependent sex determination in the leopard gecko (Eublepharis macularius): response to Kratochvil et al.
豹纹守宫 (Eublepharis maulousius) 温度依赖性性别决定的限制:对 Kratochvil 等人的回应。
- DOI:10.1007/s00114-008-0433-5
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Huang,Victoria;Sakata,JonT;Rhen,Turk;Coomber,Patricia;Simmonds,Sarah;Crews,David
- 通讯作者:Crews,David
Cytochrome oxidase activity in the preoptic area correlates with differences in sexual behavior of intact and castrated male leopard geckos (Eublepharis macularius).
视前区的细胞色素氧化酶活性与完整和去势雄性豹纹守宫(Eublepharis maulousius)的性行为差异相关。
- DOI:10.1037/0735-7044.118.4.857
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Sakata,JT;Crews,D
- 通讯作者:Crews,D
Normally occurring intersexuality and testosterone induced plasticity in the copulatory system of adult leopard geckos.
正常发生的两性和睾丸激素诱导成年豹纹守宫交配系统的可塑性。
- DOI:10.1016/j.yhbeh.2004.11.020
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Holmes,MelissaM;Putz,Oliver;Crews,David;Wade,Juli
- 通讯作者:Wade,Juli
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David P Crews的其他文献
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{{ truncateString('David P Crews', 18)}}的其他基金
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
- 批准号:
9117556 - 财政年份:2013
- 资助金额:
$ 18.21万 - 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
- 批准号:
8595128 - 财政年份:2013
- 资助金额:
$ 18.21万 - 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
- 批准号:
8898800 - 财政年份:2013
- 资助金额:
$ 18.21万 - 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
- 批准号:
8728234 - 财政年份:2013
- 资助金额:
$ 18.21万 - 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
- 批准号:
9321838 - 财政年份:2013
- 资助金额:
$ 18.21万 - 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干扰物对大脑的性别二态性影响
- 批准号:
8205524 - 财政年份:2011
- 资助金额:
$ 18.21万 - 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干扰物对大脑的性别二态性影响
- 批准号:
8475402 - 财政年份:2011
- 资助金额:
$ 18.21万 - 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干扰物对大脑的性别二态性影响
- 批准号:
8843433 - 财政年份:2011
- 资助金额:
$ 18.21万 - 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain and behavior
内分泌干扰物对大脑和行为的性别二态性影响
- 批准号:
9565756 - 财政年份:2011
- 资助金额:
$ 18.21万 - 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干扰物对大脑的性别二态性影响
- 批准号:
8663703 - 财政年份:2011
- 资助金额:
$ 18.21万 - 项目类别: