Symposium on Organisms with Slow Aging

描述（由申请人提供）：2002年9月20日至21日，Caleb E。Finch，玛丽安·伯林格和罗伯特·E. Ricklefs计划在南加州大学召开第二届慢老化生物研讨会（SOSA-2）。SOSA-2将以2000年9月举行的SOSA-1为基础。SOSA-I考虑了一些生物体显示出非常缓慢的衰老的证据，这些生物体具有与人类衰老过程相关的抗衰老机制。例子包括脊椎动物，无脊椎动物和植物，跨度在人类和更远的范围内。 SOSA-2将进一步建立器官老化参数的比较数据库。该数据库将提供一个基于网络的来源，随时提供从各种物种和门收集的纵向数据。这些个体的纵向数据将吸引更多的研究人员，因为这些新的机会可以用于衰老的数学模型或衰老的生物化学和分子研究的新模型。选定的发言者将讨论他们自己的纵向数据集，并被要求在比较和数据方面根据公认的标准评价他们的数据的效用。工作标准包括以下类别：人口统计学（特定年龄的死亡率和生育力）;分子（例如，氧化损伤和端粒DNA长度）;细胞生理学变化（例如细胞更新、神经内分泌/内分泌功能）;和大体病理学（透镜混浊/白内障和关节炎）。具体目标是讨论动物模型中的纵向数据;组织建立一个比较数据库;招募新的调查人员和受训人员对具有延长生殖时间表和极端长寿的生物体进行比较研究。一个志愿者海报会议将扩大正式计划的生物体范围，并支持学生和迄今为止尚未确定这一新领域的研究人员进一步发展兴趣。

DESCRIPTION (provided by applicant): On September 20-21, 2002, Caleb E. Finch, Mary Ann Ottinger, and Robert E. Ricklefs plan to convene the second Symposium on Organisms with Slow Aging (SOSA-2) at the University of Southern California. SOSA-2 will build on SOSA-1 held September 2000. SOSA-I considered evidence that some organisms show very slow aging with anti-aging mechanisms that are pertinent to human aging processes. Examples included vertebrates, invertebrates, and plants with spans in the range of humans and beyond. SOSA-2 will further build a comparative database for parameters of organismic aging. This database will provide a web-based source of readily available longitudinal data that have been collected from a variety of species and phyla. These individual, longitudinal data will attract additional researchers by these new opportunities for mathematical models of aging or new models for biochemical and molecular studies of aging. Selected speakers will address their own longitudinal data sets and be asked to evaluate the utility of their data in terms of recognized criteria in a comparative and dadistic context. The working criteria include the following categories: demographic (age-specific mortality rates and fecundity); molecular (e.g., oxidative damage and telomere DNA length); cellular-physiological change (e.g. cell turnover, neuroendocrine/endocrine function); and gross pathology (lens opacity/cataracts and arthritis). Specific aims are to discuss longitudinal data in animal models; organize the building of a comparative database; and recruit new investigators and trainees to the comparative study of organisms with extended reproductive schedules and extreme longevity. A volunteer poster session will expand the range of organisms on the formal program and support the development of further interests by students and by researchers not so far identified with this new area.