Gordon Research Conference: Muscle: Contractile Proteins

描述（由申请人提供）：2002年请求部分支持 戈登研究会议肌肉：收缩蛋白质汇集在一起 生物化学家、细胞生物学家和生理学家， 肌肉收缩的机制及其调节。而肌动蛋白肌球蛋白 收缩系统已被最广泛的研究，它现在是很好的 认识到基于acto肌球蛋白的系统在许多疾病中具有重要作用， 从细胞器运输到细胞分裂的细胞活动。的 会议的总体重点将是肌肉的分子基础 收缩。虽然骨骼肌收缩一直是主要的焦点， 在过去的这个会议上，一个重要的数据库正在生成， 通过对其他肌肉和非肌肉收缩系统的研究。因此 本次会议将强调比较方法， 研究许多不同成员的科学家的演讲和讨论 肌球蛋白超家族以及其他分子马达（例如驱动蛋白）。是 预计肌肉界的科学家将受益于 通过了解肌球蛋白的功能范围而获得的见解， 可能会出现在其他运动系统中。有两个主要目标。一是 讨论该领域最近的重要发展， 确定的分子结构，以单分子研究在溶液中， 纤维，因为它们与收缩机制有关。在过去的十年里， 肌动蛋白和肌球蛋白的原子分辨率结构的可用性，技术 用于研究单分子，改进的EM成像方法， 研究转基因分子已经彻底改变了 收缩过程这些问题、模型和基本假设， 这些新的发展。会议的第二个目标是集中讨论 主要问题，模型和有争议的问题，根据最近的结果， 基于研讨会。将有九个会议，其中将有 少数几次正式发言，然后是一次讨论讲习班， 与会议有关的关键问题。讨论将由 会议主席和会议海报主席，他们将共同负责 将海报参与者纳入讨论。

DESCRIPTION (provided by applicant): Partial support is requested for the 2002 Gordon Research Conference Muscle: Contractile Proteins to bring together biophysicists, biochemists, cell biologists and physiologists to address the mechanism of muscle contraction and its regulation. While the actin myosin contractile system has been the most extensively studied, it is now well recognized that acto myosin based systems have fundamental roles in many cellular activities ranging from organelle transport to cell division. The overall focus of the conference will be the Molecular Basis of Muscle Contraction. Although skeletal muscle contraction has been the primary focus of this conference in the past, a significant database is now being generated through studies of other muscle and nonmuscle contractile systems. Therefore, a comparative approach will be emphasized at this conference by having presentations and discussions by scientists who study many different members of the myosin superfamily as well as other molecular motors (e.g. kinesin). It is anticipated that scientists in the muscle community will benefit from the insights gained by understanding the range of functional capacities that myosin may exhibit in other motile systems. There are two major aims. One is to discuss important recent developments in the field ranging from newly determined molecular structures to single molecule studies in solution and in fibers as they relate to the contractile mechanism. In the past decade the availability of atomic resolution structures for actin and myosin, techniques for studying single molecules, improved EM imaging methods, and the opportunity to study genetically modified molecules have revolutionized the study of the contractile process. The questions, models, and underlying assumptions, predate these newer developments. The second aim of the conference is to focus on the major questions, models and controversial issues in light of recent results in discussion based workshops. There will be nine sessions in which there will be a small number of formal presentations followed by a discussion workshop on critical issues relating to the session. The discussions will be led by the Session Chair and a Session Poster Chair who will together be responsible for incorporating the poster participants into the discussion.