Validation of Galectin-3 as a Target in Cancer Therapy
Galectin-3 作为癌症治疗靶点的验证
基本信息
- 批准号:6572632
- 负责人:
- 金额:$ 14.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-05-08 至 2004-04-30
- 项目状态:已结题
- 来源:
- 关键词:apoptosis bacterial virus biotechnology cell adhesion cell line cell proliferation drug discovery /isolation extracellular matrix proteins galactosides gene expression gene induction /repression genetic library hepatocellular carcinoma lectin messenger RNA molecular biology neoplasm /cancer invasiveness neoplasm /cancer therapy nucleic acid hybridization oligonucleotides peptides tissue /cell culture
项目摘要
DESCRIPTION (provided by applicant):
Galectins are a recently recognized family of evolutionarily conserved
-galactoside-binding animal lectins. Family members are involved in
immunomodulation, induction and inhibition of cell death, cell cycle control,
cell adhesion and association with tumors. Current trends indicate that
galectins will serve as important diagnostic agents, prognostic indicators and
therapeutic agents for a variety of neoplastic diseases.
We have identified galectin-3 as a potential molecular target of intervention
in several tumor types. The protein is upregulated in thyroid carcinoma,
hapatocellular carcinoma, and certain types of lymphomas: normal thyroid
epithelial cells, hepatocytes, and lymphocytes do not express galectin-3, but
the corresponding cancerous tissue express the protein highly. We have
demonstrated galectin-3's involvement in promoting proliferation of a leukemic
tumor cell line under suboptimal growth conditions, and in inhibition of
apoptosis. Many chemotherapeutic agents function by induction of apoptosis,
and galectin-3 may reasonably be expected to contribute to therapeutic
resistance by virtue of its function in the regulation of apoptosis. Recent
high throughput screening data suggest that chemosensitivity of tumor cells is
inversely related to the levels of galectin-3 expressed. Galectin-3 has also
been shown to play a role in homotypic cell adhesion and adhesion of cells to
extracellular matrix proteins. In addition, by transfection experiments,
other investigators have related galectin-3 expression to the metastatic
property of cancer cells. Thus, inhibitors of galectin-3 may be useful for
treatment of cancers and our application seeks to validate galectin-3 as a
potential therapeutic target with the following Specific Aims:
1. Development of inhibitors of galectin-3 expression. Galectin-3-specific
antisense oligodeoxynucleotides will be generated and used to inhibit the
expression of galectin-3 protein in cells. The effect of these inhibitors on
cell growth and apoptosis of hepatocellular carcinoma cells will be evaluated.
2. Development of inhibitors of galectin-3 function. Oligonucleotide ligands
(aptamers) for galectin-3 capable of selectively neutralizing galectin-3
function will be selected. Peptide inhibitors of galectin-3 will also be
identified by the phage display technology. The effect of these inhibitors
on adhesion of cancer cells to extracellular matrix proteins and invasive
properties of cancer cells will be evaluated.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FU-TONG LIU其他文献
FU-TONG LIU的其他文献
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{{ truncateString('FU-TONG LIU', 18)}}的其他基金
DEVELOPMENT OF NONHUMAN PRIMATE MODELS OF ATOPIC DERMATITIS
特应性皮炎非人灵长类动物模型的开发
- 批准号:
8357349 - 财政年份:2011
- 资助金额:
$ 14.84万 - 项目类别:
Galectin-3 in regulation of allergic skin inflammation
Galectin-3 调节过敏性皮肤炎症
- 批准号:
7785910 - 财政年份:2010
- 资助金额:
$ 14.84万 - 项目类别:
DEVELOPMENT OF NONHUMAN PRIMATE MODELS OF ATOPIC DERMATITIS
特应性皮炎非人灵长类动物模型的开发
- 批准号:
8172632 - 财政年份:2010
- 资助金额:
$ 14.84万 - 项目类别:
Galectin-3 in regulation of allergic skin inflammation
Galectin-3 调节过敏性皮肤炎症
- 批准号:
8401847 - 财政年份:2010
- 资助金额:
$ 14.84万 - 项目类别:
Galectin-3 in regulation of allergic skin inflammation
Galectin-3 调节过敏性皮肤炎症
- 批准号:
8206814 - 财政年份:2010
- 资助金额:
$ 14.84万 - 项目类别:
Galectin-3 in regulation of allergic skin inflammation
Galectin-3 调节过敏性皮肤炎症
- 批准号:
8013555 - 财政年份:2010
- 资助金额:
$ 14.84万 - 项目类别:
Regulation of Skin Wound Epithelialization by Galectin-3
Galectin-3 调节皮肤伤口上皮化
- 批准号:
7470573 - 财政年份:2007
- 资助金额:
$ 14.84万 - 项目类别:
Regulation of Skin Wound Epithelialization by Galectin-3
Galectin-3 调节皮肤伤口上皮化
- 批准号:
7315928 - 财政年份:2007
- 资助金额:
$ 14.84万 - 项目类别:
Validation of Galectin-3 as a Target in Cancer Therapy
Galectin-3 作为癌症治疗靶点的验证
- 批准号:
6640748 - 财政年份:2002
- 资助金额:
$ 14.84万 - 项目类别:
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