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DEVELOPING AN ANIMAL MODEL FOR ATOPIC DERMATITIS

DEVELOPING AN ANIMAL MODEL FOR ATOPIC DERMATITIS
开发特应性皮炎动物模型
批准号：
6265238
负责人：
FU-TONG LIU
金额：
$2.74万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265238
关键词：
SCID mouse atopic dermatitis clinical research disease /disorder model helper T lymphocyte human subject model design /development

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中文摘要
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英文摘要
This study is aimed at developing an animal model for atopic dermatitis, since no good animal model for this condition yet exists. It involvesisolating peripheral blood mononuclear cells (PBMC's) from atopic dermatitispatients. PBMC's (specifically CD4+ T cells) have been shown to be involved in the pathogenesis of this disorder. Once the PBMC's have been isolated from the atopic donors, they are engrafted into SCID mice. After the PBMC's have engrafted, antigens are introduced to the murine skin, in an attempt to trigger human CD4+ cell infiltration into the skin. Skin biopsies are then obtained for histological analysis, along with analysis for various cytokines (by RNA detection) to see if the atopic dermatitis phenotype has arisen.
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