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IGE BINDING PROTEIN IN PATIENTS W/ ALLERGIC DISEASE

IGE BINDING PROTEIN IN PATIENTS W/ ALLERGIC DISEASE
过敏性疾病患者中的 IGE 结合蛋白
批准号：
6307314
负责人：
FU-TONG LIU
金额：
$2.74万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6307314
关键词：
asthma atopic dermatitis binding proteins clinical research human subject hypersensitivity immunoglobulin E protein biosynthesis

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中文摘要
翻译
该方案的目的是研究IgE结合蛋白，现在被称为Galectin-3，在过敏性炎症中的作用。现有数据表明Galectin-3可能是炎症的放大因子。这种蛋白在各种炎症细胞中表达，我们的假设是，由于各种炎症介质的刺激，患有过敏性疾病的人体内Galectin-3表达上调。该议定书由两个具体目标组成。第一个是关于包括哮喘和特应性皮炎在内的过敏性疾病患者血清中Galectin-3水平的定量，第二个是关于过敏性疾病患者炎性细胞中Galectin-3表达的分析。
英文摘要
The purpose of this protocol is to study the role of IgE-binding protein, now known as galectin-3, in allergic inflammation. Existing data suggest that galectin-3 may be an amplifier of imflammation. This protein is expressed in various inflammatory cells and our hypothesis is that galectin-3 is upregulated in individuals with allergic diseases as a result of stimulation by various imflammatory mediators. The protocol cosists of two specific aims. The first deals with the quantitation of the level of galectin-3 in sera of patients with allergic diseases, including asthma and atopic dermatitis, and the second concerns the analysis of the expression of galectin-3 in inflammatory cells from patients with allergic diseases.
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DEVELOPMENT OF NONHUMAN PRIMATE MODELS OF ATOPIC DERMATITIS
Galectin-3 in regulation of allergic skin inflammation
DEVELOPMENT OF NONHUMAN PRIMATE MODELS OF ATOPIC DERMATITIS
Galectin-3 in regulation of allergic skin inflammation
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