IGE BINDING PROTEIN IN PATIENTS W/ ALLERGIC DISEASE

过敏性疾病患者中的 IGE 结合蛋白

• 批准号: 6307314
• 负责人: FU-TONG LIU
• 金额: $ 2.74万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307314
• 关键词: asthma; atopic dermatitis; binding proteins; clinical research; human subject; hypersensitivity; immunoglobulin E; protein biosynthesis

The purpose of this protocol is to study the role of IgE-binding protein, now known as galectin-3, in allergic inflammation. Existing data suggest that galectin-3 may be an amplifier of imflammation. This protein is expressed in various inflammatory cells and our hypothesis is that galectin-3 is upregulated in individuals with allergic diseases as a result of stimulation by various imflammatory mediators. The protocol cosists of two specific aims. The first deals with the quantitation of the level of galectin-3 in sera of patients with allergic diseases, including asthma and atopic dermatitis, and the second concerns the analysis of the expression of galectin-3 in inflammatory cells from patients with allergic diseases.

本方案的目的是研究IgE结合蛋白（现在称为半乳糖凝集素-3）在过敏性炎症中的作用。 现有的数据表明，半乳糖凝集素-3可能是炎症的放大器。这种蛋白质在各种炎性细胞中表达，我们的假设是半乳糖凝集素-3在过敏性疾病个体中由于各种炎性介质的刺激而上调。 该协议包括两个具体目标。 第一个涉及过敏性疾病，包括哮喘和特应性皮炎患者血清中半乳糖凝集素-3水平的定量，第二个涉及过敏性疾病患者炎性细胞中半乳糖凝集素-3表达的分析。