CHEMICAL-BIOLOGY INTERFACE TRAINING GRANT

这是培训拨款申请T32 GM08804的重新提交。我们设计了一个跨学科的计划，在生物、药物和传统化学的界面上培训学生(和教师)，称为生物化学计划(BCP)。该项目始于2000年秋季，为对生物化学感兴趣的学生提供有重点的、跨学科的教育。一旦完全参与，我们设想在任何给定的时间都有40-50名学生参与BCP。该项目完全融入了三个参与的系，学生可以获得化学、生物化学和分子方面的学位 生物物理学或药物化学，同时参加生物化学培训计划。这项建议是为培训补助金提供支持，允许向该方案中最优秀的学生颁发四个奖学金，每个奖学金为期两年(每年总共8个奖项)。奖学金将在学生第二学期结束时颁发，在被盗之前选择论文导师，并将允许学生更自由地选择论文主题，并为学生参加全国会议提供资金。学生们将在BCP中保持活跃，直到毕业。培训人员包括35名 来自四个部门的高度活跃的研究小组。之前的投稿因我们的培训教师、我们对跨学科研究的承诺、我们互动、融洽的学术环境以及我们最先进的研究设施而获得赞誉。确定的主要问题是，我们的学生还不多。另外两个次要的问题是，我们的管理和课程的所有方面都没有得到实施。在过去的一年里，我们成功地招收了12名新生，使我们的项目总数达到16名。在这些人中，有7人是培训助学金。我们程序的各个方面，包括专门为程序设计的新课程，现在都准备好了。对修订后的提案进行了修改，以反映这些进步，并解决了审查员的所有关切。

This is a resubmission of training grant application T32 GM08804. We have designed an interdisciplinary program for training students (and faculty) at the interface of biological, medicinal, and traditional chemistry, called the Biological Chemistry Program (BCP). This program, which began in the fall of 2000, provides a focused, cross-disciplinary education for students interested in biological chemistry. Once fully engaged, we envision 40 - 50 students participating in the BCP at any given time. The program is fully integrated into the three participating departments and students may obtain a degree in Chemistry, Biochemistry and Molecular Biophysics, or Medicinal Chemistry while participating in the Biological Chemistry Training Program. This proposal is for training grant support that would allow four fellowships pe_: year to be awarded to the best students in the program for a period of two years each (8 total awards per year). The fellowships will be awarded at the end of the student's second semester, before theft choose a thesis advisor, and will allow the student more freedom in choosing a thesis topic as well as provide funds for student travel to national meetings. The students will remain active in the BCP until graduation. The training faculty include 35 highly active research groups from four departments. The previous submission received hitch praise for our training faculty, our commitment to interdisciplinary research, our interactive, congenial academic environment, and our state-of-the-art research facilities. The major concern identified was that we did not yet have many students. Two more minor concerns were that not all aspects of our administration and curriculum were implemented. In the past year, we have successfully recruited 12 new students to our program, bringing us to 16 total. Of these, 7 are training grant eIigible. /El aspects of our prog-ram, including a new course specifically desig-ned for the prog-ram, are now in place. The revised proposal has been modified to reflect these advances and addresses all of the reviewers' concerns.